Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 564..1141 Replicon plasmid pJSRIV004_1
Accession NZ_CP074141
Organism Serratia sp. JSRIV004

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KGP21_RS28880 Protein ID WP_223498409.1
Coordinates 564..896 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KGP21_RS28885 Protein ID WP_223498408.1
Coordinates 896..1141 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP21_RS28875 (KGP21_28780) 236..550 - 315 WP_223498410.1 hypothetical protein -
KGP21_RS28880 (KGP21_28785) 564..896 - 333 WP_223498409.1 endoribonuclease MazF Toxin
KGP21_RS28885 (KGP21_28790) 896..1141 - 246 WP_223498408.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KGP21_RS28890 (KGP21_28795) 1309..1515 - 207 WP_223498407.1 hypothetical protein -
KGP21_RS28895 (KGP21_28800) 1673..1903 - 231 WP_223498406.1 hypothetical protein -
KGP21_RS28900 (KGP21_28805) 1900..2223 - 324 WP_223498405.1 hypothetical protein -
KGP21_RS28905 (KGP21_28810) 2246..2485 - 240 WP_223498404.1 helix-turn-helix domain-containing protein -
KGP21_RS28910 (KGP21_28815) 2747..3241 - 495 WP_223498403.1 hypothetical protein -
KGP21_RS28915 (KGP21_28820) 3470..4297 - 828 WP_223498402.1 phosphoenolpyruvate hydrolase family protein -
KGP21_RS28920 (KGP21_28825) 4294..4770 - 477 Protein_9 Tm-1-like ATP-binding domain-containing protein -
KGP21_RS28925 (KGP21_28830) 4833..5528 - 696 WP_223498400.1 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - fimD / fimC 1..114761 114761


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-107)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11901.85 Da        Isoelectric Point: 8.4953

>T201600 WP_223498409.1 NZ_CP074141:c896-564 [Serratia sp. JSRIV004]
MVKGYVPDAGDIVWLEFDPQAGHEQAGHRPALVLSPAVYNGRIGLMLCCPMTTKIKGYPFEVIVPGERESAVLADQVKSL
DWKERNATKKGQVPASVLSDVRAKAKALIG

Download         Length: 333 bp

>T201600 NZ_CP098690:1237392-1237535 [Rickettsia rickettsii]
ATGAGAGATCATGCCCTTATAGGTAATTGGAAAGATTGTAGAGATTGTCATATTAAAGCGGATTTAGTATTAATTTATAG
AAAACCCGATGCTGACACATTGGAGTTAATACAATTAGGTTCAAACAGTACACTTGGTTTTTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8600.94 Da        Isoelectric Point: 4.9861

>AT201600 WP_223498408.1 NZ_CP074141:c1141-896 [Serratia sp. JSRIV004]
MSQVVVKKWGNSPSVRLPVAVMKAASLNVDDTVEVSVEEGRIVIVPVRAKVYSLDGLLAGVTDENIHQAVSFGEPVGKEA
L

Download         Length: 246 bp

>AT201600 NZ_CP098690:1237037-1237300 [Rickettsia rickettsii]
ATGTCTGCTGATTCTATTGTGCGAGCCCGTATTAATGAAGACGTGAAAGAAGAAGCAGCTTTAGTGCTTGCTGCTATGGG
ACTTACTTTATCTGATGCTGTTCGTATGCTGTTATTTCGTGTTGCTCGTGAAAAAGCATTGCCGTTTGAACCACTTATCC
CAAATGATGAAACAATTAAAGCTATGAAAGCTGCAAGAAGCGGCAAATTAGTTCATGTTGGTAATATCAATAATTTGTTA
TCTGATTTAAATGAGAACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References