Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE(toxin)
Location 5281986..5282508 Replicon chromosome
Accession NZ_CP074140
Organism Serratia sp. JSRIV004

Toxin (Protein)


Gene name relE Uniprot ID A0A0U4JRE1
Locus tag KGP21_RS25055 Protein ID WP_021806920.1
Coordinates 5282227..5282508 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0U4HY11
Locus tag KGP21_RS25050 Protein ID WP_021806919.1
Coordinates 5281986..5282237 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP21_RS25025 (KGP21_24935) 5277535..5278344 - 810 WP_094983166.1 SDR family oxidoreductase -
KGP21_RS25030 (KGP21_24940) 5278341..5278997 - 657 WP_021180630.1 iron-containing redox enzyme family protein -
KGP21_RS25035 (KGP21_24945) 5278994..5280433 - 1440 WP_094983167.1 AMP-dependent synthetase/ligase -
KGP21_RS25040 (KGP21_24950) 5280430..5281074 - 645 WP_021806917.1 thermostable hemolysin -
KGP21_RS25045 (KGP21_24955) 5281268..5281921 + 654 WP_223536434.1 Qnr family pentapeptide repeat protein -
KGP21_RS25050 (KGP21_24960) 5281986..5282237 + 252 WP_021806919.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KGP21_RS25055 (KGP21_24965) 5282227..5282508 + 282 WP_021806920.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP21_RS25060 (KGP21_24970) 5282677..5283312 + 636 WP_218520259.1 glutathione transferase -
KGP21_RS25065 (KGP21_24975) 5283423..5284877 - 1455 WP_021180637.1 NAD-dependent succinate-semialdehyde dehydrogenase -
KGP21_RS25070 (KGP21_24980) 5284890..5286155 - 1266 WP_166733462.1 4-aminobutyrate--2-oxoglutarate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10991.89 Da        Isoelectric Point: 10.6704

>T201598 WP_021806920.1 NZ_CP074140:5282227-5282508 [Serratia sp. JSRIV004]
MTYKLKFEKRALKEWEKLGYPVREQLKKKLAERLENPHVPASRLSGRPNRYKIKLRSSGYRLVYEVRDNEIVLLVIAVGK
RAGEEVYFAADKR

Download         Length: 282 bp

>T201598 NZ_CP098688:1249230-1249373 [Rickettsia rickettsii]
ATGAGAGATCATGCCCTTATAGGTAATTGGAAAGATTGTAGAGGTTGTCATATTAAAGCGGATTTAGTATTAATTTATAG
AAAACCCGATGCTGACACATTGGAGTTAATACAATTAGGTTCAAACAGTACACTTGGTTTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9243.37 Da        Isoelectric Point: 3.7947

>AT201598 WP_021806919.1 NZ_CP074140:5281986-5282237 [Serratia sp. JSRIV004]
MAFQILTTIAASITDLKKNPMGTVADGEGEAVAILNRNEPAFYCVPPELYAYYRELAEDAELNRIADERMEDAEFVSVDL
NDL

Download         Length: 252 bp

>AT201598 NZ_CP098688:1248876-1249139 [Rickettsia rickettsii]
ATGTCTGCTGATTCTATTGTGCGAGCCCGTATTAATGAAGACGTGAAAGAAGAAGCAGCTTTAGTGCTTGCTGCTATGGG
ACTTACTTTATCTGATGCTGTTCGTATGCTGTTATTTCGTGTTGCTCGTGAAAAAGCATTGCCGTTTGAACCACTTATCC
CAAATGATGAAACAATTAAAGCTATGAAAGCTGCAAGAAGCGGCAAATTAGTTCATGTTGGTAATATCAATAATTTGTTA
TCTGATTTAAATGAGAACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U4JRE1

Antitoxin

Source ID Structure
AlphaFold DB A0A0U4HY11

References