Detailed information of TA system TA201597

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 5100763..5101318
• Replicon: chromosome
• Accession: NZ_CP074140
• Organism: Serratia sp. JSRIV004

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KGP21_RS29600
• Protein ID: WP_245398320.1
• Coordinates: 5101184..5101318 (+)
• Length: 45 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KGP21_RS24320
• Protein ID: WP_223498456.1
• Coordinates: 5100763..5101044 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP21_RS24275 (KGP21_24185)	5096060..5096512	+	453	WP_223498447.1	hypothetical protein	-
KGP21_RS24280 (KGP21_24190)	5096509..5096961	+	453	WP_223498448.1	IrmA family protein	-
KGP21_RS24285 (KGP21_24195)	5097107..5097541	+	435	WP_223498449.1	antirestriction protein	-
KGP21_RS24290 (KGP21_24200)	5097559..5098047	+	489	WP_223498450.1	DNA repair protein RadC	-
KGP21_RS24295 (KGP21_24205)	5098041..5098361	+	321	WP_223498451.1	DUF5983 family protein	-
KGP21_RS24300 (KGP21_24210)	5098425..5098907	+	483	WP_223498452.1	hypothetical protein	-
KGP21_RS24305 (KGP21_24215)	5098920..5099255	+	336	WP_223498453.1	TA system toxin CbtA family protein	-
KGP21_RS24310 (KGP21_24220)	5099333..5099710	+	378	WP_223498454.1	type IV toxin-antitoxin system YeeU family antitoxin	-
KGP21_RS24315 (KGP21_24225)	5099789..5100646	+	858	WP_223498455.1	DUF4942 domain-containing protein	-
KGP21_RS24320 (KGP21_24230)	5100763..5101044	+	282	WP_223498456.1	ribbon-helix-helix domain-containing protein	Antitoxin
KGP21_RS29600	5101184..5101318	+	135	WP_245398320.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGP21_RS24330 (KGP21_24240)	5101610..5102722	-	1113	WP_223500374.1	M20 family metallopeptidase	-
KGP21_RS24335 (KGP21_24245)	5102819..5103280	-	462	WP_115159346.1	YjiG family protein	-
KGP21_RS24340 (KGP21_24250)	5103297..5104031	-	735	WP_155621780.1	nucleoside recognition domain-containing protein	-
KGP21_RS24345 (KGP21_24255)	5104563..5105366	-	804	WP_223500375.1	histidine phosphatase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-43)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 45 a.a.
• Molecular weight: 5538.39 Da
• Isoelectric Point: 10.5247

>T201597 WP_245398320.1 NZ_CP074140:5101184-5101318 [Serratia sp. JSRIV004]
MRPALARYEPREVRRLNIGNYEIHYELRVNALYILRVWHTRENR

Nucleotide

• Length: 135 bp

>T201597 NZ_CP098611:3205519-3205779 [Phormidium yuhuli AB48]
ATGAAGGTAAGTTTTACTGAGTTGGCTTGGTCTGATTATCTCTGGCTACAAAAGAAGGATAAGAGGCTTTTAAAACGGGT
AAATCTTCTGATTAAAGATGTGATGAGGGATGCGTTTGAGGGGATTGGCAAGCCAGAACCTTTGAAGGGAAATTTATCGG
GTTACTGGTCAAGGCGGATTGATGGGGAGCATCGTTTGGTGTATCAGGTGGTTGGAGATGAAATTTTAATTATTTCCTGT
CGGTTTCACTATGAAAGATGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10503.87 Da
• Isoelectric Point: 4.8000

>AT201597 WP_223498456.1 NZ_CP074140:5100763-5101044 [Serratia sp. JSRIV004]
MGQSPTRVITAHVPAEMVEKFDELAANYDRSRGWIVKQVLAANIEQEENHHQMILRGLADVDESRVVEQTDVLKWINSLN
IDTPLPVPQSGQK

Nucleotide

• Length: 282 bp

>AT201597 NZ_CP098611:3205268-3205522 [Phormidium yuhuli AB48]
ATGAAAACCATTGAAACTCAACAAGCCAAACAGCAATTAGATGAGATGATTGACCAGGTTATTATAGATGTTGAACCGAC
AATCCTACGGAATCAAAAGGGTCAAGAAGCGGTTTTGATGTCGTTAGAAGAGTTTAGTGCTTGGCGGGAAACGATTTATC
TTTTATCCAATCCAGCCAATGCGTCTCATCTTCTTGAATCTATCAAGCAGGCTGAGTCAGGTCAGACTATCCTCAAGGAA
CTTCTGGATGAATGA