Detailed information of TA system TA201592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3695185..3695814
• Replicon: chromosome
• Accession: NZ_CP074140
• Organism: Serratia sp. JSRIV004

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0F7HGI5
• Locus tag: KGP21_RS17745
• Protein ID: WP_021805694.1
• Coordinates: 3695185..3695373 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KGP21_RS17750
• Protein ID: WP_021805695.1
• Coordinates: 3695401..3695814 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP21_RS17735 (KGP21_17665)	3693203..3693841	-	639	WP_021805692.1	TetR/AcrR family transcriptional regulator	-
KGP21_RS17740 (KGP21_17670)	3694050..3694985	+	936	WP_021805693.1	nitronate monooxygenase	-
KGP21_RS17745 (KGP21_17675)	3695185..3695373	+	189	WP_021805694.1	type II toxin-antitoxin system HicA family toxin	Toxin
KGP21_RS17750 (KGP21_17680)	3695401..3695814	+	414	WP_021805695.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KGP21_RS17755 (KGP21_17685)	3695847..3696599	-	753	WP_021805696.1	L-cystine ABC transporter ATP-binding protein TcyN	-
KGP21_RS17760 (KGP21_17690)	3696603..3697265	-	663	WP_021180972.1	cystine ABC transporter permease	-
KGP21_RS17765 (KGP21_17695)	3697265..3698065	-	801	WP_021180971.1	cystine ABC transporter substrate-binding protein	-
KGP21_RS17770 (KGP21_17700)	3698184..3699170	-	987	WP_021805697.1	D-cysteine desulfhydrase	-
KGP21_RS17775 (KGP21_17705)	3699297..3699806	-	510	WP_021805698.1	flagella biosynthesis regulatory protein FliZ	-
KGP21_RS17780 (KGP21_17710)	3699867..3700589	-	723	WP_021180968.1	RNA polymerase sigma factor FliA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fliZ / fliA	3695152..3700589	5437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7005.17 Da
• Isoelectric Point: 11.1589

>T201592 WP_021805694.1 NZ_CP074140:3695185-3695373 [Serratia sp. JSRIV004]
VKSSELIKRLESHGWVLQRIKGSHHQFKHPNSSLVITVPHPNKDVKLGTLRQIMKDAGLLNS

Nucleotide

• Length: 189 bp

>T201592 NZ_CP098611:940160-940489 [Phormidium yuhuli AB48]
ATGGGAGTGGTAGCCCAGCGTTTTGATGTTTTTTTGGTTAATCTTGACCCGACAATTGGCAGTGAAATTCAGAAAACACG
ACCCTGTGTGATTATATCACCGGATGAAATGAACCGCCATATTGCCACGGTAATTATTGCACCAATGACGACAAAAGGGA
AAGCCTACCCGACGCGAATTCCCTGCCAGTTTCAGGGTAAGGAAGGGAAAATTGTTCTGGATCAAATCCGCACCATTGAT
AAAACTCGATTGGTCAAAAAACTGGGTCAAATTAGTCCAGATGAGCAAAGTGGAGTTCTCGACACCTTGGCTGAGATGTT
TTCCGAATGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15056.86 Da
• Isoelectric Point: 5.0801

>AT201592 WP_021805695.1 NZ_CP074140:3695401-3695814 [Serratia sp. JSRIV004]
MFYPAYIHAEPDGSASGFFPDVPGCYFAGVSLDQTFQDAKSALDAHFELLSENNQVIPRPQAVSFHLAQDNDALNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDALVQQHPGYGSRSAFLAAAARNELLKAG

Nucleotide

• Length: 414 bp

>AT201592 NZ_CP098611:939912-940172 [Phormidium yuhuli AB48]
ATGAGCAAAGTGATTAGAACCCGAATTGTTAAAATTGGCAACTCCCAAGGTGTGCGTATTCCTAAACTACTCTTAGAGCA
AAGCGGTATTCAGGCAGATGTTGAAATTGAAGTGGAGGGCGATCATCTCACGATTCGCACCGCACGACGGTTACGCAACG
GCTGGGATCAAGCCTTTGCAGCAATGGCGAAAGAACAAGATGATGTTCTTCTGGATCAAGTCAACAGTACCGACTGGGAG
CAAAGTGAATGGGAGTGGTAG

Structures

Toxin

• AlphaFold DB: A0A0F7HGI5