Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1572176..1572798 Replicon chromosome
Accession NZ_CP074140
Organism Serratia sp. JSRIV004

Toxin (Protein)


Gene name Hha Uniprot ID U2M374
Locus tag KGP21_RS07285 Protein ID WP_021180142.1
Coordinates 1572176..1572379 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID U2NAN4
Locus tag KGP21_RS07290 Protein ID WP_021180141.1
Coordinates 1572430..1572798 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP21_RS07260 (KGP21_07230) 1568007..1568495 + 489 WP_021180151.1 YbaY family lipoprotein -
KGP21_RS07265 (KGP21_07235) 1568550..1568864 - 315 WP_021180150.1 MGMT family protein -
KGP21_RS07275 (KGP21_07245) 1569244..1571031 - 1788 WP_179252232.1 adenine deaminase C-terminal domain-containing protein -
KGP21_RS07280 (KGP21_07250) 1571168..1572094 + 927 WP_021805469.1 LysR family transcriptional regulator -
KGP21_RS07285 (KGP21_07255) 1572176..1572379 - 204 WP_021180142.1 HHA domain-containing protein Toxin
KGP21_RS07290 (KGP21_07260) 1572430..1572798 - 369 WP_021180141.1 Hha toxicity modulator TomB Antitoxin
KGP21_RS07295 (KGP21_07265) 1572960..1573313 - 354 WP_094981218.1 hypothetical protein -
KGP21_RS07300 (KGP21_07270) 1573693..1574385 + 693 WP_223537618.1 ABC transporter ATP-binding protein -
KGP21_RS07305 (KGP21_07275) 1574385..1575242 + 858 WP_094981189.1 metal ABC transporter permease -
KGP21_RS07310 (KGP21_07280) 1575268..1576146 + 879 WP_209528380.1 zinc ABC transporter substrate-binding protein -
KGP21_RS07315 (KGP21_07285) 1576254..1576394 - 141 WP_021805462.1 type B 50S ribosomal protein L36 -
KGP21_RS07320 (KGP21_07290) 1576407..1576664 - 258 WP_021180135.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8099.48 Da        Isoelectric Point: 6.9770

>T201582 WP_021180142.1 NZ_CP074140:c1572379-1572176 [Serratia sp. JSRIV004]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T201582 NZ_CP098604:c1977223-1977071 [Xanthomonas hortorum pv. pelargonii]
ATGAAGCGACTGCTGACACTGATGGTGCTAGGCCTGTTTTCGGCTGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
CGGCAAGGACATGCAGGGCGCAGGTGAGAAGGTCGAAAAGAAGGCCGATAATTGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14097.78 Da        Isoelectric Point: 4.5140

>AT201582 WP_021180141.1 NZ_CP074140:c1572798-1572430 [Serratia sp. JSRIV004]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSFKIKYMDEGDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARTFRLFSGEGVCTTMKT

Download         Length: 369 bp

>AT201582 NZ_CP098604:c1976992-1976858 [Xanthomonas hortorum pv. pelargonii]
ATGAAGCGTGCAATTATGCTGCTGGTGCTGTCGGTGTTTTCGGTCGGTATGTTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAAGTGGAAGACGCTGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2M374

Antitoxin

Source ID Structure
AlphaFold DB U2NAN4

References