Detailed information of TA system TA201577

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 556314..556861
• Replicon: chromosome
• Accession: NZ_CP074140
• Organism: Serratia sp. JSRIV004

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KGP21_RS02465
• Protein ID: WP_245398412.1
• Coordinates: 556583..556861 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A7Y8XL57
• Locus tag: KGP21_RS02460
• Protein ID: WP_059201942.1
• Coordinates: 556314..556583 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP21_RS02445 (KGP21_02430)	551370..555194	+	3825	WP_223537052.1	translocation/assembly module TamB domain-containing protein	-
KGP21_RS02450 (KGP21_02435)	555197..555547	+	351	WP_024483355.1	gamma-glutamylcyclotransferase	-
KGP21_RS02455 (KGP21_02440)	555598..556125	-	528	WP_021179028.1	inorganic diphosphatase	-
KGP21_RS02460 (KGP21_02445)	556314..556583	+	270	WP_059201942.1	hypothetical protein	Antitoxin
KGP21_RS02465 (KGP21_02450)	556583..556861	+	279	WP_245398412.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGP21_RS02470 (KGP21_02455)	557039..558592	+	1554	WP_166733941.1	methyl-accepting chemotaxis protein	-
KGP21_RS02475 (KGP21_02460)	558627..559631	-	1005	WP_029711176.1	class 1 fructose-bisphosphatase	-
KGP21_RS02480 (KGP21_02465)	559802..561181	+	1380	WP_024483358.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-
KGP21_RS02485 (KGP21_02470)	561394..561657	-	264	WP_021179031.1	peroxide/acid stress response protein YhcN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10984.56 Da
• Isoelectric Point: 6.4886

>T201577 WP_245398412.1 NZ_CP074140:556583-556861 [Serratia sp. JSRIV004]
MEIVWTQLASEDRRKIREYIAENNLRAAIELDERIGSMANSLAEHPLKGREGRVKETRELVIHPHFIEVYRVVNEWERIE
IIRVLHTAQQWP

Nucleotide

• Length: 279 bp

>T201577 NZ_CP098549:c3161-2883 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9950.18 Da
• Isoelectric Point: 5.8375

>AT201577 WP_059201942.1 NZ_CP074140:556314-556583 [Serratia sp. JSRIV004]
MTQTTLNLRIDTELKTDFLEAAKAMDRNGSQLIRDFMRETVQRQHDIWFRDQVQAGIAQANRGEVLSGESVEASAVAWRE
AAAKKLAGS

Nucleotide

• Length: 270 bp

>AT201577 NZ_CP098549:c3346-3161 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Structures

Antitoxin

• AlphaFold DB: A0A7Y8XL57