Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2266085..2266611 Replicon chromosome
Accession NZ_CP073936
Organism Escherichia coli strain MB56

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KFU61_RS10900 Protein ID WP_000323025.1
Coordinates 2266324..2266611 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KFU61_RS10895 Protein ID WP_000534858.1
Coordinates 2266085..2266324 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU61_RS10865 (2261447) 2261447..2261936 + 490 Protein_2120 class I SAM-dependent methyltransferase -
KFU61_RS10870 (2262414) 2262414..2262835 + 422 Protein_2121 hypothetical protein -
KFU61_RS10875 (2263491) 2263491..2264513 + 1023 Protein_2122 ISNCY family transposase -
KFU61_RS10880 (2264634) 2264634..2264783 + 150 WP_011443592.1 protein YdfW -
KFU61_RS10885 (2265220) 2265220..2265552 - 333 WP_001301033.1 FlxA-like family protein -
KFU61_RS10890 (2265755) 2265755..2266060 - 306 WP_001326990.1 protein YdfV -
KFU61_RS10895 (2266085) 2266085..2266324 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KFU61_RS10900 (2266324) 2266324..2266611 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KFU61_RS10905 (2266683) 2266683..2266838 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
KFU61_RS10910 (2266896) 2266896..2268170 + 1275 Protein_2129 primase-like DNA-binding domain-containing protein -
KFU61_RS10915 (2268458) 2268458..2268703 + 246 WP_000125506.1 hypothetical protein -
KFU61_RS10920 (2268700) 2268700..2269149 + 450 Protein_2131 single-stranded DNA-binding protein -
KFU61_RS10925 (2269367) 2269367..2270407 + 1041 WP_000228111.1 major capsid protein -
KFU61_RS10930 (2270417) 2270417..2270758 + 342 WP_000190773.1 head decoration protein -
KFU61_RS10935 (2270770) 2270770..2271153 + 384 WP_001178672.1 AlpA family phage regulatory protein -
KFU61_RS10940 (2271399) 2271399..2271593 + 195 WP_000453554.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage blaCTX-M-32 - 2241213..2308440 67227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T200660 WP_000323025.1 NZ_CP073936:2266324-2266611 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T200660 NZ_CP098135:46002-46472 [Klebsiella pneumoniae]
GTGATCTTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT200660 WP_000534858.1 NZ_CP073936:2266085-2266324 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT200660 NZ_CP098135:45562-46005 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References