Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3684226..3685024 Replicon chromosome
Accession NZ_CP073929
Organism Escherichia coli strain MB64

Toxin (Protein)


Gene name yeeV Uniprot ID A0A166U9J9
Locus tag KFU91_RS17605 Protein ID WP_000854695.1
Coordinates 3684226..3684603 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2U2UUE3
Locus tag KFU91_RS17610 Protein ID WP_016243360.1
Coordinates 3684650..3685024 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU91_RS17575 (3679504) 3679504..3680460 + 957 WP_000121346.1 molybdenum cofactor insertion chaperone PaoD -
KFU91_RS17580 (3680511) 3680511..3680849 + 339 Protein_3439 LysR substrate-binding domain-containing protein -
KFU91_RS17585 (3681187) 3681187..3682506 + 1320 WP_191007492.1 site-specific integrase -
KFU91_RS17590 (3682599) 3682599..3683447 - 849 WP_001280536.1 DUF4942 domain-containing protein -
KFU91_RS17595 (3683532) 3683532..3683729 - 198 WP_000839228.1 DUF957 domain-containing protein -
KFU91_RS17600 (3683741) 3683741..3684229 - 489 WP_000761710.1 DUF5983 family protein -
KFU91_RS17605 (3684226) 3684226..3684603 - 378 WP_000854695.1 TA system toxin CbtA family protein Toxin
KFU91_RS17610 (3684650) 3684650..3685024 - 375 WP_016243360.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KFU91_RS17615 (3685187) 3685187..3685408 - 222 WP_000692307.1 DUF987 domain-containing protein -
KFU91_RS17620 (3685477) 3685477..3685953 - 477 WP_001186773.1 RadC family protein -
KFU91_RS17625 (3685969) 3685969..3686448 - 480 WP_000860084.1 antirestriction protein -
KFU91_RS17630 (3686530) 3686530..3687348 - 819 WP_001241366.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE 3654682..3686448 31766


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14062.03 Da        Isoelectric Point: 7.7531

>T200612 WP_000854695.1 NZ_CP073929:c3684603-3684226 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPGAKQ

Download         Length: 378 bp

>T200612 NZ_CP098040:c3345245-3345042 [Providencia rettgeri]
ATGACCAAATCTGATTATCTGATGCGTTTAAGAAAATGCACCACAATTGAAACACTTGAGCGTGTCATTGAAAAAAATAA
GTATGAATTATCTGATGATGAGCTAGAGCTATTCTATTCAGCAGCAGATCACCGCTTAGCTGAACTCACAATGAATAAGC
TTTATGATAAAATCCCAGCGTCTGTTTGGAAGTTTGTTAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13810.66 Da        Isoelectric Point: 7.0266

>AT200612 WP_016243360.1 NZ_CP073929:c3685024-3684650 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT200612 NZ_CP098040:c3345688-3345320 [Providencia rettgeri]
ATGGATGAATACTCACCCAAAAGACATGATATAGCAGAACTAAAATACTTATGTAATAGTCTCAATAGAGACGCTATTTT
AAGCTTACAAAAAACAAATACACACTGGATTAATGATTTAAGCTCCCCGCAAAGCGCAGCCTTGAATGAACTCATTGAAC
ATATCGCTGCATTTGTATGGCGGTTTAAAATCAAATACCCAAAAGAAAATCTTGTTATATCACTTATCGAAGAATACCTC
GATGAGACCTATGATTTATTCGGCAGCCCAGTTATCACACTTAGTGAAATTATAGACTGGGAAGCAATGAATCACAGCCT
TGTCGCTGTGCTGGATGATGACCTAAAGTGCCTAACCAGCAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A166U9J9

Antitoxin

Source ID Structure
AlphaFold DB A0A2U2UUE3

References