Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2574214..2575802 Replicon chromosome
Accession NZ_CP073791
Organism Klebsiella pneumoniae isolate KP_NORM_BLD_2010_71621

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag KFO61_RS12555 Protein ID WP_002904792.1
Coordinates 2574480..2575802 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag KFO61_RS12550 Protein ID WP_002904790.1
Coordinates 2574214..2574480 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFO61_RS12525 (KFO61_12520) 2569364..2570287 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
KFO61_RS12530 (KFO61_12525) 2570268..2571422 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
KFO61_RS12535 (KFO61_12530) 2571768..2573147 + 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
KFO61_RS12540 (KFO61_12535) 2573125..2573625 + 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KFO61_RS12545 (KFO61_12540) 2573622..2573948 + 327 WP_002904788.1 hydroxyisourate hydrolase -
KFO61_RS12550 (KFO61_12545) 2574214..2574480 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KFO61_RS12555 (KFO61_12550) 2574480..2575802 + 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
KFO61_RS12560 (KFO61_12555) 2575819..2577111 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
KFO61_RS12565 (KFO61_12560) 2577253..2578257 - 1005 WP_002904798.1 fimbrial protein -
KFO61_RS12570 (KFO61_12565) 2578245..2580746 - 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T200292 WP_002904792.1 NZ_CP073791:2574480-2575802 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T200292 NZ_CP097807:c405794-405396 [Thalassospira sp. GO-4]
ATGCTGCGGTTCATGCTTGATACCAATATCTGCATCTATGTCATCAAGAACCGCCCGGCCTCCTGCCGCGAGAAGTTCCG
CACCCATAGCGGTGCGATGGCAATTTCATCGGTGACACTTGCAGAATTGATTTATGGCGCCATGAAATCGGCCAAACCCG
AAAGCAACCTTCGCACCATCGAAGAATTTGCTGCACGCCTGAGTGTTCTTGATTTCGATACCGATGCCGCCGGTCATTAT
GGCGATATCCGAAGCACACTTGAACGCGAAGGCAACGTCATCGGGCCATATGACATGATGATTGCCGGTCATGCGCGCAG
TCACGGCCTTATCCTTGTCACCAATAACACCCGTGAATTTGAACGGGTCGACGGCTTACGGCTGGAGAACTGGGTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT200292 WP_002904790.1 NZ_CP073791:2574214-2574480 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT200292 NZ_CP097807:c406024-405794 [Thalassospira sp. GO-4]
ATGACGCAAGCATCCGTATTCCTGAACAACAAGACGCAGGCCGTGCGCCTGCCCAAGGATGTCGCCTTTCCCGAAGGCAC
AAAAACGGTTGAAGTGATCTCGGTCGGGGTGACCCGCGTGATCGTCCCAAGCGACCATCTTTGGGATACGTTCTTTGATG
GTCATGCCGTCAGTGACGATTTCATGGAAGACCGAAACCAGCCCGCCATGCAGGAACGGGATGGGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References