Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
| Location | 2016581..2017212 | Replicon | chromosome |
| Accession | NZ_CP073791 | ||
| Organism | Klebsiella pneumoniae isolate KP_NORM_BLD_2010_71621 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A1Q8YTV3 |
| Locus tag | KFO61_RS09695 | Protein ID | WP_012542177.1 |
| Coordinates | 2016581..2016757 (+) | Length | 59 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A2X1QFN9 |
| Locus tag | KFO61_RS09700 | Protein ID | WP_012542176.1 |
| Coordinates | 2016805..2017212 (+) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFO61_RS09670 (KFO61_09665) | 2011883..2012914 | + | 1032 | WP_047670001.1 | DUF968 domain-containing protein | - |
| KFO61_RS09675 (KFO61_09670) | 2012927..2013271 | + | 345 | WP_032447265.1 | antiterminator Q family protein | - |
| KFO61_RS09680 (KFO61_09675) | 2013361..2014404 | + | 1044 | WP_020803204.1 | DNA cytosine methyltransferase | - |
| KFO61_RS09685 (KFO61_09680) | 2014370..2015059 | - | 690 | WP_012542179.1 | MAE_28990/MAE_18760 family HEPN-like nuclease | - |
| KFO61_RS09690 (KFO61_09685) | 2015061..2016218 | - | 1158 | WP_020803203.1 | DUF262 domain-containing protein | - |
| KFO61_RS09695 (KFO61_09690) | 2016581..2016757 | + | 177 | WP_012542177.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KFO61_RS09700 (KFO61_09695) | 2016805..2017212 | + | 408 | WP_012542176.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KFO61_RS09705 (KFO61_09700) | 2017368..2017604 | + | 237 | WP_004111739.1 | class II holin family protein | - |
| KFO61_RS09710 (KFO61_09705) | 2017582..2018112 | + | 531 | WP_023328100.1 | lysozyme | - |
| KFO61_RS09715 (KFO61_09710) | 2018145..2018621 | + | 477 | WP_050516738.1 | DUF2514 domain-containing protein | - |
| KFO61_RS09720 (KFO61_09715) | 2018657..2018863 | + | 207 | WP_032447250.1 | hypothetical protein | - |
| KFO61_RS09725 (KFO61_09720) | 2018847..2019209 | + | 363 | WP_020803185.1 | HNH endonuclease | - |
| KFO61_RS09730 (KFO61_09725) | 2019161..2019478 | + | 318 | WP_020803188.1 | hypothetical protein | - |
| KFO61_RS09735 (KFO61_09730) | 2019475..2019906 | + | 432 | WP_077255824.1 | hypothetical protein | - |
| KFO61_RS09740 (KFO61_09735) | 2020156..2020590 | + | 435 | WP_012542168.1 | phage terminase small subunit P27 family | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1996552..2049845 | 53293 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6632.83 Da Isoelectric Point: 11.0174
>T200291 WP_012542177.1 NZ_CP073791:2016581-2016757 [Klebsiella pneumoniae]
VKQSELRRWLAAQGAEFKDGTNHLKIYLNGKQTVMPRHPGKEIPEPLRKAILKQLGIK
VKQSELRRWLAAQGAEFKDGTNHLKIYLNGKQTVMPRHPGKEIPEPLRKAILKQLGIK
Download Length: 177 bp
>T200291 NZ_CP097804:4344811-4345062 [Xanthomonas oryzae pv. oryzae]
ATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGATGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGGGATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAA
GCGGGGTACTGA
ATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGATGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGGGATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAA
GCGGGGTACTGA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14977.99 Da Isoelectric Point: 4.4277
>AT200291 WP_012542176.1 NZ_CP073791:2016805-2017212 [Klebsiella pneumoniae]
MRYPVIFEHDETGWAVFFPDIPEAMTGGETREEALEMAQDALVTAFDFYFDDRREIPAPSAEGDAFVEVPASVAAKVLLL
NRLVSTNTSNADLARMINTRPQEVQRIVSLGHSTKIDTIQKALSALGQKMEIVVH
MRYPVIFEHDETGWAVFFPDIPEAMTGGETREEALEMAQDALVTAFDFYFDDRREIPAPSAEGDAFVEVPASVAAKVLLL
NRLVSTNTSNADLARMINTRPQEVQRIVSLGHSTKIDTIQKALSALGQKMEIVVH
Download Length: 408 bp
>AT200291 NZ_CP097804:4344506-4344784 [Xanthomonas oryzae pv. oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCTAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCTAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1Q8YTV3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2X1QFN9 |