Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1184268..1184887 Replicon chromosome
Accession NZ_CP073791
Organism Klebsiella pneumoniae isolate KP_NORM_BLD_2010_71621

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KFO61_RS05710 Protein ID WP_002892050.1
Coordinates 1184268..1184486 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KFO61_RS05715 Protein ID WP_002892066.1
Coordinates 1184513..1184887 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFO61_RS05675 (KFO61_05675) 1180315..1180578 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
KFO61_RS05680 (KFO61_05680) 1180578..1180718 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KFO61_RS05685 (KFO61_05685) 1180715..1181413 - 699 WP_002892021.1 GNAT family protein -
KFO61_RS05690 (KFO61_05690) 1181514..1182965 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KFO61_RS05695 (KFO61_05695) 1182940..1183410 - 471 WP_002892026.1 YlaC family protein -
KFO61_RS05700 (KFO61_05700) 1183431..1183571 + 141 WP_004147370.1 hypothetical protein -
KFO61_RS05705 (KFO61_05705) 1183543..1184109 - 567 WP_002892030.1 maltose O-acetyltransferase -
KFO61_RS05710 (KFO61_05710) 1184268..1184486 - 219 WP_002892050.1 HHA domain-containing protein Toxin
KFO61_RS05715 (KFO61_05715) 1184513..1184887 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KFO61_RS05720 (KFO61_05720) 1185373..1188519 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KFO61_RS05725 (KFO61_05725) 1188542..1189735 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T200289 WP_002892050.1 NZ_CP073791:c1184486-1184268 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T200289 NZ_CP097804:2490143-2490424 [Xanthomonas oryzae pv. oryzae]
GTGATCAGGAGCTTTATCGACAAGGACGCCGAAAAGATCTGGCTGGGTGAGCGTTCCCGCCGGTTGCCTGCCGACATCCA
ATTGGTCGCGCGCCGCAAGTTGCGCATGCTCAATGCCGCCGCACATCTCGACGATCTGCGGATCCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCGGCGCGGCCAGTACAGCATCCGGATCAACGATCAATGGCGCATCTGCTTCCGATGGATG
GAAGGCGATGTGGTCCAGGTCGAAATCGTCGATTACCACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT200289 WP_002892066.1 NZ_CP073791:c1184887-1184513 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT200289 NZ_CP097804:2490442-2490732 [Xanthomonas oryzae pv. oryzae]
ATGACGGTCCTACCCAATATCCATCCTGGCGACATTCTGCTTGAGGAGTTTCTCGAGCCTCTGGGCATCAGCCAGAATGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGCACCTCCGAGCGCTTCTGGCTGGGCCTGCAGGCCGACTACGAGCTGGAACAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCACGGATCAAGCGGCTGGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References