Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 717427..718214 Replicon chromosome
Accession NZ_CP073718
Organism Escherichia coli strain CX08

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6L5EGB6
Locus tag J6O57_RS03560 Protein ID WP_032669201.1
Coordinates 717837..718214 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A6L5EE19
Locus tag J6O57_RS03555 Protein ID WP_023567998.1
Coordinates 717427..717786 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O57_RS03510 (712688) 712688..713401 + 714 WP_032669194.1 WYL domain-containing protein -
J6O57_RS03515 (713398) 713398..714033 + 636 WP_020837117.1 hypothetical protein -
J6O57_RS03520 (714072) 714072..714527 + 456 WP_000754598.1 hypothetical protein -
J6O57_RS03525 (714524) 714524..714973 + 450 WP_032669197.1 IrmA family protein -
J6O57_RS03530 (715045) 715045..715276 + 232 Protein_692 DUF905 domain-containing protein -
J6O57_RS03535 (715375) 715375..716196 + 822 WP_032669198.1 DUF932 domain-containing protein -
J6O57_RS03540 (716227) 716227..716670 + 444 WP_032669199.1 antirestriction protein -
J6O57_RS03545 (716682) 716682..717161 + 480 WP_032669200.1 DNA repair protein RadC -
J6O57_RS03550 (717182) 717182..717403 + 222 WP_023567997.1 DUF987 domain-containing protein -
J6O57_RS03555 (717427) 717427..717786 + 360 WP_023567998.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J6O57_RS03560 (717837) 717837..718214 + 378 WP_032669201.1 TA system toxin CbtA family protein Toxin
J6O57_RS03565 (718211) 718211..718702 + 492 WP_032672023.1 DUF5983 family protein -
J6O57_RS03570 (718732) 718732..718935 + 204 WP_032669203.1 DUF957 domain-containing protein -
J6O57_RS03575 (718999) 718999..719847 + 849 WP_032669204.1 DUF4942 domain-containing protein -
J6O57_RS03585 (720150) 720150..720656 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
J6O57_RS03590 (720735) 720735..722576 - 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14157.93 Da        Isoelectric Point: 6.2236

>T200077 WP_032669201.1 NZ_CP073718:717837-718214 [Escherichia coli]
MQTQPLSSTQEATPRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLSSIDILRARKATGLMTRNDYRTVTDITTGKYREVQP

Download         Length: 378 bp

>T200077 NZ_CP097701:9262-9612 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13192.04 Da        Isoelectric Point: 6.3122

>AT200077 WP_023567998.1 NZ_CP073718:717427-717786 [Escherichia coli]
MSNEIPTVNHDITEPWWGLKRSITPCFGARLVQAGNRLHYLADRANITGQFSDADLRYLDQAFPLLLKQLELMLTSGELN
PCHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA

Download         Length: 360 bp

>AT200077 NZ_CP097701:9617-9919 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L5EGB6

Antitoxin

Source ID Structure
AlphaFold DB A0A6L5EE19

References