Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3060710..3061386 Replicon chromosome
Accession NZ_CP073262
Organism Duffyella gerundensis strain AR

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag J9874_RS14075 Protein ID WP_225701037.1
Coordinates 3060710..3061030 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag J9874_RS14080 Protein ID WP_225701038.1
Coordinates 3061063..3061386 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9874_RS14060 (J9874_02810) 3056210..3057526 - 1317 WP_225701034.1 McrC family protein -
J9874_RS14065 (J9874_02811) 3057523..3059583 - 2061 WP_225701035.1 McrB family protein -
J9874_RS14070 (J9874_02812) 3059766..3060596 - 831 WP_225701036.1 DUF4942 domain-containing protein -
J9874_RS14075 (J9874_02813) 3060710..3061030 - 321 WP_225701037.1 TA system toxin CbtA family protein Toxin
J9874_RS14080 (J9874_02814) 3061063..3061386 - 324 WP_225701038.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J9874_RS14085 (J9874_02815) 3061418..3061888 - 471 WP_263867884.1 DNA repair protein RadC -
J9874_RS14090 (J9874_02816) 3061957..3062235 - 279 WP_225701039.1 hypothetical protein -
J9874_RS14095 (J9874_02817) 3062395..3063216 - 822 WP_225701040.1 DUF932 domain-containing protein -
J9874_RS14100 (J9874_02818) 3063276..3064160 - 885 WP_225701041.1 50S ribosome-binding GTPase -
J9874_RS14105 (J9874_02819) 3064249..3065106 - 858 WP_225701042.1 hypothetical protein -
J9874_RS14110 (J9874_02820) 3065557..3066144 + 588 WP_225701043.1 inovirus-type Gp2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3056210..3082187 25977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-105)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12062.68 Da        Isoelectric Point: 5.0486

>T199633 WP_225701037.1 NZ_CP073262:c3061030-3060710 [Duffyella gerundensis]
MQISSVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDATIEEHIEAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLTATDILRARRATGLINT

Download         Length: 321 bp

>T199633 NZ_CP097426:2605259-2605366 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12024.63 Da        Isoelectric Point: 6.7066

>AT199633 WP_225701038.1 NZ_CP073262:c3061386-3061063 [Duffyella gerundensis]
MALSVSQEWGLRSNITPRFGARLVQEGNRLHYLADRAELTGSFTPEQLQKLDRAFPLFIEQLENSLRSGELNPCQQHRVG
VHIAGLTCIADTLGSYGYVYISIYPTQ

Download         Length: 324 bp

>AT199633 NZ_CP097426:c2605212-2605146 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References