Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2382878..2383448 Replicon chromosome
Accession NZ_CP073089
Organism Brevibacterium sp. W7.2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J9315_RS10795 Protein ID WP_211977862.1
Coordinates 2383167..2383448 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J9315_RS10790 Protein ID WP_198498450.1
Coordinates 2382878..2383180 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9315_RS10760 2378216..2379352 + 1137 WP_198498456.1 glycerol dehydrogenase -
J9315_RS10765 2379470..2379739 + 270 WP_211977857.1 DUF3263 domain-containing protein -
J9315_RS10770 2379765..2380913 - 1149 WP_211977858.1 heme-binding protein -
J9315_RS10775 2381137..2381490 - 354 WP_211977859.1 DUF1801 domain-containing protein -
J9315_RS10780 2381736..2382137 - 402 WP_249120887.1 GNAT family N-acetyltransferase -
J9315_RS10785 2382321..2382881 - 561 WP_211977861.1 GNAT family N-acetyltransferase -
J9315_RS10790 2382878..2383180 - 303 WP_198498450.1 HigA family addiction module antitoxin Antitoxin
J9315_RS10795 2383167..2383448 - 282 WP_211977862.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J9315_RS10800 2383555..2384436 - 882 WP_211977863.1 helix-turn-helix transcriptional regulator -
J9315_RS10805 2384574..2385818 + 1245 WP_211977864.1 MFS transporter -
J9315_RS10810 2385853..2386896 + 1044 WP_211977865.1 zinc-dependent alcohol dehydrogenase family protein -
J9315_RS10815 2386883..2387287 - 405 WP_211977866.1 hypothetical protein -
J9315_RS10820 2387911..2388210 + 300 WP_211977867.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2382660..2391800 9140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10960.50 Da        Isoelectric Point: 9.8460

>T199573 WP_211977862.1 NZ_CP073089:c2383448-2383167 [Brevibacterium sp. W7.2]
VIRSFGDKETERLWHRERVRSIDPRILRVALRKLRQVGSAEYLVDLRVPPGNRLEALKGDRAGQHSIRINDRWRICFAWT
DAGPEEVEIVDYH

Download         Length: 282 bp

>T199573 NZ_CP097411:c2647495-2646173 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTACTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCTACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11064.59 Da        Isoelectric Point: 4.8255

>AT199573 WP_198498450.1 NZ_CP073089:c2383180-2382878 [Brevibacterium sp. W7.2]
MTTTDKIEPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLARYFGTSAEFWINLQSHYEL
DRAEELAGEQIASITPLSVA

Download         Length: 303 bp

>AT199573 NZ_CP097411:c2647761-2647495 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References