Detailed information of TA system TA199567

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3570434..3571655
• Replicon: chromosome
• Accession: NZ_CP073082
• Organism: Pseudomonas aeruginosa strain WTJH17

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KCG37_RS16350
• Protein ID: WP_003114949.1
• Coordinates: 3571077..3571655 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KCG37_RS16345
• Protein ID: WP_003088112.1
• Coordinates: 3570434..3570988 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KCG37_RS16320 (KCG37_16320)	3566002..3566553	+	552	WP_003102727.1	XRE family transcriptional regulator	-
KCG37_RS16325 (KCG37_16325)	3566550..3566948	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
KCG37_RS16330 (KCG37_16330)	3566961..3567284	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
KCG37_RS16335 (KCG37_16335)	3567615..3568076	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
KCG37_RS16340 (KCG37_16340)	3568081..3570276	+	2196	WP_003122807.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
KCG37_RS16345 (KCG37_16345)	3570434..3570988	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
KCG37_RS16350 (KCG37_16350)	3571077..3571655	+	579	WP_003114949.1	HD domain-containing protein	Toxin
KCG37_RS16355 (KCG37_16355)	3571763..3572950	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
KCG37_RS16360 (KCG37_16360)	3572940..3575111	-	2172	WP_003088105.1	type I secretion system permease/ATPase	-
KCG37_RS16365 (KCG37_16365)	3575101..3576378	-	1278	WP_003122808.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21897.75 Da
• Isoelectric Point: 5.3655

>T199567 WP_003114949.1 NZ_CP073082:3571077-3571655 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Nucleotide

• Length: 579 bp

>T199567 NZ_CP097389:23026-23511 [Klebsiella pneumoniae]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT199567 WP_003088112.1 NZ_CP073082:3570434-3570988 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT199567 NZ_CP097389:22772-23038 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA