Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 2845971..2846550 | Replicon | chromosome |
| Accession | NZ_CP073012 | ||
| Organism | Staphylococcus aureus strain SA14+ | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | KAJ74_RS14030 | Protein ID | WP_001025401.1 |
| Coordinates | 2845971..2846216 (+) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 2846185..2846550 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAJ74_RS13975 (KAJ74_13975) | 2841263..2841877 | + | 615 | WP_001636974.1 | phage protein | - |
| KAJ74_RS13980 (KAJ74_13980) | 2841874..2842020 | - | 147 | WP_113342690.1 | hypothetical protein | - |
| KAJ74_RS13985 (KAJ74_13985) | 2842250..2842834 | - | 585 | WP_165622152.1 | hypothetical protein | - |
| KAJ74_RS13990 (KAJ74_13990) | 2842852..2843313 | - | 462 | WP_000525004.1 | hypothetical protein | - |
| KAJ74_RS13995 (KAJ74_13995) | 2843326..2843640 | - | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | - |
| KAJ74_RS14000 (KAJ74_14000) | 2843792..2844028 | + | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| KAJ74_RS14005 (KAJ74_14005) | 2844042..2844818 | + | 777 | WP_031912592.1 | Rha family transcriptional regulator | - |
| KAJ74_RS14010 (KAJ74_14010) | 2844847..2844990 | + | 144 | WP_000939498.1 | hypothetical protein | - |
| KAJ74_RS14325 | 2844980..2845270 | - | 291 | WP_094321613.1 | uracil-DNA glycosylase | - |
| KAJ74_RS14020 (KAJ74_14020) | 2845340..2845537 | + | 198 | WP_001148860.1 | hypothetical protein | - |
| KAJ74_RS14025 (KAJ74_14025) | 2845524..2845904 | - | 381 | WP_000773059.1 | DUF2513 domain-containing protein | - |
| KAJ74_RS14030 (KAJ74_14030) | 2845971..2846216 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| KAJ74_RS14035 (KAJ74_14035) | 2846185..2846550 | - | 366 | WP_001128433.1 | hypothetical protein | Antitoxin |
| KAJ74_RS14040 (KAJ74_14040) | 2846605..2846820 | + | 216 | WP_001097552.1 | hypothetical protein | - |
| KAJ74_RS14045 (KAJ74_14045) | 2846847..2847110 | + | 264 | WP_001124196.1 | helix-turn-helix domain-containing protein | - |
| KAJ74_RS14050 (KAJ74_14050) | 2847123..2847284 | + | 162 | WP_001285948.1 | DUF1270 domain-containing protein | - |
| KAJ74_RS14055 (KAJ74_14055) | 2847379..2847681 | + | 303 | WP_001608484.1 | DUF2482 family protein | - |
| KAJ74_RS14060 (KAJ74_14060) | 2847686..2847946 | + | 261 | WP_031584888.1 | DUF1108 family protein | - |
| KAJ74_RS14065 (KAJ74_14065) | 2847956..2848177 | + | 222 | WP_000815401.1 | DUF2483 family protein | - |
| KAJ74_RS14070 (KAJ74_14070) | 2848170..2848793 | + | 624 | WP_000139720.1 | DUF1071 domain-containing protein | - |
| KAJ74_RS14075 (KAJ74_14075) | 2848793..2849218 | + | 426 | WP_165619096.1 | single-stranded DNA-binding protein | - |
| KAJ74_RS14080 (KAJ74_14080) | 2849229..2849780 | + | 552 | WP_001004506.1 | NUMOD4 domain-containing protein | - |
| KAJ74_RS14085 (KAJ74_14085) | 2849781..2850455 | + | 675 | WP_210967561.1 | putative HNHc nuclease | - |
| KAJ74_RS14090 (KAJ74_14090) | 2850448..2851203 | + | 756 | WP_165619727.1 | DnaD domain protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T199502 WP_001025401.1 NZ_CP073012:2845971-2846216 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T199502 NZ_CP097367:c4122911-4122534 [Escherichia coli]
ATGAAAACATTACCTGATACACACGTACGGAAGGTATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCTGATACACACGTACGGAAGGTATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 366 bp
>AT199502 NZ_CP073012:c2846550-2846185 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
