Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 1582540..1583135 Replicon chromosome
Accession NZ_CP072980
Organism Escherichia coli strain 2547

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag KBW66_RS07575 Protein ID WP_000239579.1
Coordinates 1582785..1583135 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag KBW66_RS07570 Protein ID WP_001223208.1
Coordinates 1582540..1582791 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBW66_RS07560 (1578205) 1578205..1581984 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
KBW66_RS07565 (1581987) 1581987..1582328 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
KBW66_RS07570 (1582540) 1582540..1582791 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
KBW66_RS07575 (1582785) 1582785..1583135 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
KBW66_RS07580 (1583215) 1583215..1583745 - 531 WP_000055075.1 inorganic diphosphatase -
KBW66_RS07585 (1584055) 1584055..1585011 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
KBW66_RS07590 (1585151) 1585151..1586653 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
KBW66_RS07595 (1586667) 1586667..1587689 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T199364 WP_000239579.1 NZ_CP072980:1582785-1583135 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T199364 NZ_CP097329:3057005-3057256 [Pseudanabaena mucicola str. Chao 1806]
ATGAACGCAGTTTCTTATGTTGAGGCACAGAGCAACTTAGCAAAAATGATCGATCAAGTATGTGACAATCATGATCCAGT
AGTCATAACACGCCACCAACAACCATCCGCAGTGCTTCTATCACTTGAAGATTATGAATCTCTGGCAGAAACTGCTTACC
TTTTAAAAAGTCGTAATAATGCTAAGCGAATTTTTGAGGCGATCGCTGAATTAGAATCTGGCGGTGGTACTGTGCGGGAG
CTGATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT199364 WP_001223208.1 NZ_CP072980:1582540-1582791 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT199364 NZ_CP097329:3057253-3057507 [Pseudanabaena mucicola str. Chao 1806]
GTGAAACTTATTTTTTCAGAGCGTGCTTGGGAAGATTATCTTTACTGGCAAAAAACAGACAAAAAAATATTGAATCGAAT
CAATAGTCTGATTAAAGATATTCAACGAGATCCATACAGTGGTATTGGCAAGCCAGAAGCTTTAAAACATGGATTGTCGG
GATATTGGTCTAGGCGTATCGATGATGAGCATAGGATTCTTTACAAGGTTGAAGATAATGCACTTTTATTAGTTCAGATT
CGTTATCACTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References