Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
| Location | 266590..267179 | Replicon | chromosome |
| Accession | NZ_CP072904 | ||
| Organism | Bartonella henselae strain Marseille/ URLLY-8 | ||
Toxin (Protein)
| Gene name | pemK | Uniprot ID | X5M710 |
| Locus tag | KAE73_RS01280 | Protein ID | WP_011180620.1 |
| Coordinates | 266590..266922 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | pemI | Uniprot ID | X5MFI8 |
| Locus tag | KAE73_RS01285 | Protein ID | WP_038487501.1 |
| Coordinates | 266922..267179 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAE73_RS01270 (KAE73_01250) | 266026..266271 | - | 246 | WP_082251654.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAE73_RS01275 (KAE73_01255) | 266255..266482 | - | 228 | WP_007346764.1 | DUF6290 family protein | - |
| KAE73_RS01280 (KAE73_01260) | 266590..266922 | - | 333 | WP_011180620.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| KAE73_RS01285 (KAE73_01265) | 266922..267179 | - | 258 | WP_038487501.1 | antitoxin | Antitoxin |
| KAE73_RS01290 (KAE73_01270) | 267260..267754 | - | 495 | WP_038487773.1 | hypothetical protein | - |
| KAE73_RS01295 (KAE73_01275) | 267808..268254 | - | 447 | WP_038487775.1 | single-stranded DNA-binding protein | - |
| KAE73_RS01300 (KAE73_01280) | 268477..268701 | + | 225 | WP_038487033.1 | antitoxin MazE family protein | - |
| KAE73_RS01305 (KAE73_01285) | 268701..269024 | + | 324 | WP_082250412.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| KAE73_RS01310 (KAE73_01290) | 269118..269417 | + | 300 | WP_034448610.1 | BrnT family toxin | - |
| KAE73_RS01315 (KAE73_01295) | 269395..269700 | + | 306 | WP_034448608.1 | BrnA antitoxin family protein | - |
| KAE73_RS01320 (KAE73_01300) | 269718..270011 | + | 294 | WP_034447441.1 | HigA family addiction module antitoxin | - |
| KAE73_RS01325 (KAE73_01305) | 270053..270379 | - | 327 | WP_082251643.1 | hypothetical protein | - |
| KAE73_RS01330 (KAE73_01310) | 270561..270947 | - | 387 | WP_082246570.1 | hypothetical protein | - |
| KAE73_RS01335 (KAE73_01315) | 270931..272070 | - | 1140 | WP_038487492.1 | DUF1376 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11865.88 Da Isoelectric Point: 10.5590
>T199162 WP_011180620.1 NZ_CP072904:c266922-266590 [Bartonella henselae]
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT
Download Length: 333 bp
>T199162 NZ_CP097221:120658-121128 [Klebsiella pneumoniae]
GTGATCTTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
GTGATCTTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9439.75 Da Isoelectric Point: 4.1260
>AT199162 WP_038487501.1 NZ_CP072904:c267179-266922 [Bartonella henselae]
MHTTKLRKVGGSVMLSIPPALLDVLHLTENTQVDLAVDNGQLVVKPQTFPSYTLDELLAQCNPSDDFADEDMEWFDAKPV
GRELL
MHTTKLRKVGGSVMLSIPPALLDVLHLTENTQVDLAVDNGQLVVKPQTFPSYTLDELLAQCNPSDDFADEDMEWFDAKPV
GRELL
Download Length: 258 bp
>AT199162 NZ_CP097221:120218-120661 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067W4K9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | X5MFI8 |