199138

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 261831..262311 Replicon chromosome
Accession NZ_CP072902
Organism Bartonella henselae strain ATCC49882T var-2/ Houston-I

Toxin (Protein)


Gene name pasB Uniprot ID A0A067WDE7
Locus tag KAE74_RS01220 Protein ID WP_011180622.1
Coordinates 261831..262100 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID N6VJG4
Locus tag KAE74_RS01225 Protein ID WP_007346764.1
Coordinates 262084..262311 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE74_RS01195 (KAE74_01180) 256885..258939 - 2055 WP_011180822.1 portal protein -
KAE74_RS01200 (KAE74_01185) 258924..260249 - 1326 WP_011180823.1 phage terminase large subunit -
KAE74_RS01205 (KAE74_01190) 260230..260556 - 327 WP_011180626.1 hypothetical protein -
KAE74_RS01210 (KAE74_01195) 260855..261313 + 459 WP_011180624.1 hypothetical protein -
KAE74_RS01215 261409..261801 + 393 WP_075320637.1 hypothetical protein -
KAE74_RS01220 (KAE74_01200) 261831..262100 - 270 WP_011180622.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KAE74_RS01225 (KAE74_01205) 262084..262311 - 228 WP_007346764.1 DUF6290 family protein Antitoxin
KAE74_RS01230 (KAE74_01210) 262419..262751 - 333 WP_011180620.1 type II toxin-antitoxin system PemK/MazF family toxin -
KAE74_RS01235 (KAE74_01215) 262751..263008 - 258 WP_034448603.1 antitoxin -
KAE74_RS01240 (KAE74_01220) 263089..263583 - 495 WP_059443338.1 hypothetical protein -
KAE74_RS01245 (KAE74_01225) 263637..264083 - 447 WP_011180617.1 single-stranded DNA-binding protein -
KAE74_RS01250 (KAE74_01230) 264295..264585 + 291 WP_011180616.1 hypothetical protein -
KAE74_RS01255 (KAE74_01235) 264582..264854 + 273 WP_011180615.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
KAE74_RS01260 (KAE74_01240) 265045..265362 - 318 Protein_242 hypothetical protein -
KAE74_RS01265 (KAE74_01245) 265544..265930 - 387 WP_082246570.1 hypothetical protein -
KAE74_RS01270 (KAE74_01250) 265914..267164 - 1251 WP_011180612.1 DUF1376 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 235926..276048 40122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(2-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10495.44 Da        Isoelectric Point: 10.2009

>T199138 WP_011180622.1 NZ_CP072902:c262100-261831 [Bartonella henselae]
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQFSGLWRYRVGDYRILCELYDKELVVLVLAV
GHRKNIYKG

Download         Length: 270 bp

>T199138 NZ_CP097213:2688855-2688962 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8742.78 Da        Isoelectric Point: 4.8780

>AT199138 WP_007346764.1 NZ_CP072902:c262311-262084 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD

Download         Length: 228 bp

>AT199138 NZ_CP097213:c2688808-2688742 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A067WDE7

Antitoxin

Source ID Structure
AlphaFold DB N6VJG4

References