Detailed information of TA system TA199135

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1592588..1593215
• Replicon: chromosome
• Accession: NZ_CP072901
• Organism: Bartonella henselae strain Berlin-I

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0H3M2H0
• Locus tag: KAE72_RS06830
• Protein ID: WP_011180277.1
• Coordinates: 1592588..1592902 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: KAE72_RS06835
• Protein ID: WP_011180278.1
• Coordinates: 1592919..1593215 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAE72_RS06810 (KAE72_06675)	1588215..1589771	-	1557	WP_011180273.1	phage portal protein	-
KAE72_RS06815 (KAE72_06680)	1589771..1590019	-	249	WP_011180274.1	hypothetical protein	-
KAE72_RS06820 (KAE72_06685)	1590023..1591951	-	1929	WP_011180275.1	phage terminase large subunit family protein	-
KAE72_RS06825 (KAE72_06690)	1591944..1592525	-	582	WP_011180276.1	hypothetical protein	-
KAE72_RS06830 (KAE72_06695)	1592588..1592902	+	315	WP_011180277.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KAE72_RS06835 (KAE72_06700)	1592919..1593215	+	297	WP_011180278.1	HigA family addiction module antitoxin	Antitoxin
KAE72_RS06840 (KAE72_06705)	1593625..1593888	+	264	WP_011180280.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
KAE72_RS06845 (KAE72_06710)	1593875..1594156	+	282	WP_011180281.1	type II toxin-antitoxin system YafQ family toxin	-
KAE72_RS06850 (KAE72_06715)	1594199..1594477	-	279	WP_011180242.1	hypothetical protein	-
KAE72_RS06855 (KAE72_06720)	1594474..1595232	-	759	WP_011180282.1	phage antirepressor Ant	-
KAE72_RS06860 (KAE72_06725)	1595292..1595807	-	516	WP_011180283.1	phage antirepressor Ant	-
KAE72_RS06865 (KAE72_06730)	1595824..1596663	-	840	WP_011180284.1	antA/AntB antirepressor family protein	-
KAE72_RS06870 (KAE72_06735)	1596695..1597237	-	543	WP_011180285.1	phage antirepressor Ant	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1551314..1618522	67208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (15-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12135.97 Da
• Isoelectric Point: 9.0878

>T199135 WP_011180277.1 NZ_CP072901:1592588-1592902 [Bartonella henselae]
MIHKRTNEGDLVIESFADKRCKDLLEGNPPKGFPTTLVRIVQRKLFMLDKAVDLKDLRSPPGNRLEALKGERKGQYSIRI
NDQFRICFEWRSNGAYEVEIVDYH

Nucleotide

• Length: 315 bp

>T199135 NZ_CP097213:2386720-2388042 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11262.91 Da
• Isoelectric Point: 5.8690

>AT199135 WP_011180278.1 NZ_CP072901:1592919-1593215 [Bartonella henselae]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSRITPDTALRLASFFDTTAEFWLNMQAAYDVSVL
QAEKADEFSKISKFECRV

Nucleotide

• Length: 297 bp

>AT199135 NZ_CP097213:2386454-2386720 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3M2H0