Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2803480..2804132 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag J8397_RS13200 Protein ID WP_003412752.1
Coordinates 2803707..2804132 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag J8397_RS13195 Protein ID WP_003412749.1
Coordinates 2803480..2803701 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS13180 (J8397_13005) 2801720..2801926 - 207 WP_003899347.1 hypothetical protein -
J8397_RS13185 (J8397_13010) 2802062..2802685 + 624 WP_003900858.1 TIGR00725 family protein -
J8397_RS13190 (J8397_13015) 2802675..2803427 + 753 WP_003900859.1 hypothetical protein -
J8397_RS13195 (J8397_13020) 2803480..2803701 + 222 WP_003412749.1 antitoxin Antitoxin
J8397_RS13200 (J8397_13025) 2803707..2804132 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
J8397_RS13205 (J8397_13030) 2804155..2805336 - 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
J8397_RS13210 (J8397_13035) 2805333..2806379 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
J8397_RS13215 (J8397_13040) 2806390..2807493 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
J8397_RS13220 (J8397_13045) 2807752..2808573 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
J8397_RS13225 (J8397_13050) 2808570..2809127 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T198841 WP_003412752.1 NZ_CP072790:2803707-2804132 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T198841 NZ_CP097030:2681607-2681747 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT198841 WP_003412749.1 NZ_CP072790:2803480-2803701 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT198841 NZ_CP097030:c2681881-2681680 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTGTAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References