Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2402793..2403322 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag J8397_RS11310 Protein ID WP_003411124.1
Coordinates 2402793..2403110 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag J8397_RS11315 Protein ID WP_003411127.1
Coordinates 2403107..2403322 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS11280 (J8397_11130) 2397930..2399006 + 1077 WP_003411110.1 hypothetical protein -
J8397_RS11285 (J8397_11135) 2399003..2399284 + 282 WP_003411112.1 DUF5703 family protein -
J8397_RS11290 (J8397_11140) 2399320..2400393 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
J8397_RS11295 (J8397_11145) 2400398..2400928 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
J8397_RS11300 (J8397_11150) 2400976..2402322 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
J8397_RS11310 (J8397_11160) 2402793..2403110 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8397_RS11315 (J8397_11165) 2403107..2403322 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
J8397_RS11320 (J8397_11170) 2403577..2404635 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
J8397_RS11325 (J8397_11175) 2404765..2405121 - 357 WP_003411130.1 hypothetical protein -
J8397_RS11330 (J8397_11180) 2405216..2405998 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
J8397_RS11335 (J8397_11185) 2406266..2406556 - 291 WP_003900476.1 YggT family protein -
J8397_RS11340 (J8397_11190) 2406718..2407374 - 657 WP_003411133.1 cell division protein SepF -
J8397_RS11345 (J8397_11195) 2407440..2408216 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T198840 WP_003411124.1 NZ_CP072790:c2403110-2402793 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T198840 NZ_CP097030:2681607-2681747 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT198840 WP_003411127.1 NZ_CP072790:c2403322-2403107 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT198840 NZ_CP097030:c2681605-2681462 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References