Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1974469..1974929 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag J8397_RS09265 Protein ID WP_003898996.1
Coordinates 1974681..1974929 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag J8397_RS09260 Protein ID WP_003408528.1
Coordinates 1974469..1974681 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS09245 (J8397_09105) 1970947..1972134 - 1188 WP_003898992.1 nitrate transporter NarK -
J8397_RS09250 (J8397_09110) 1972421..1972705 + 285 WP_003408522.1 DUF1876 domain-containing protein -
J8397_RS09255 (J8397_09115) 1972719..1974401 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
J8397_RS09260 (J8397_09120) 1974469..1974681 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J8397_RS09265 (J8397_09125) 1974681..1974929 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
J8397_RS09270 (J8397_09130) 1974937..1975674 + 738 WP_003898997.1 hypothetical protein -
J8397_RS09275 (J8397_09135) 1975768..1977468 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
J8397_RS09280 (J8397_09140) 1977753..1978154 - 402 WP_003408538.1 hypothetical protein -
J8397_RS09285 (J8397_09145) 1978144..1978755 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T198829 WP_003898996.1 NZ_CP072790:1974681-1974929 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T198829 NZ_CP097023:c119894-119622 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACATATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT198829 WP_003408528.1 NZ_CP072790:1974469-1974681 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT198829 NZ_CP097023:c120157-119894 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTTGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References