Detailed information of TA system TA198328

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 2512218..2512441
• Replicon: chromosome
• Accession: NZ_CP072689
• Organism: Escherichia marmotae strain YF8

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A7H9K3A2
• Locus tag: J8I93_RS11850
• Protein ID: WP_032141347.1
• Coordinates: 2512334..2512441 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	2512218..2512284 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8I93_RS11825	2507498..2508892	-	1395	WP_000087125.1	YchO/YchP family invasin	-
J8I93_RS11830	2509076..2509429	+	354	WP_001169672.1	DsrE/F sulfur relay family protein YchN	-
J8I93_RS11835	2509473..2510168	-	696	WP_061090500.1	glutathione-specific gamma-glutamylcyclotransferase	-
J8I93_RS11840	2510326..2510556	-	231	WP_038354495.1	putative cation transport regulator ChaB	-
J8I93_RS11845	2510825..2511925	+	1101	WP_001516524.1	sodium-potassium/proton antiporter ChaA	-
-	2512218..2512284	-	67	-	-	Antitoxin
J8I93_RS11850	2512334..2512441	+	108	WP_032141347.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
J8I93_RS11855	2512621..2513475	-	855	WP_000811071.1	3-deoxy-8-phosphooctulonate synthase	-
J8I93_RS11860	2513511..2514320	-	810	WP_001257034.1	invasion regulator SirB1	-
J8I93_RS11865	2514324..2514716	-	393	WP_000200357.1	invasion regulator SirB2	-
J8I93_RS11870	2514713..2515546	-	834	WP_061090499.1	peptide chain release factor N(5)-glutamine methyltransferase	-
J8I93_RS11875	2515546..2516628	-	1083	WP_000804714.1	peptide chain release factor 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3953.71 Da
• Isoelectric Point: 11.4779

>T198328 WP_032141347.1 NZ_CP072689:2512334-2512441 [Escherichia marmotae]
MTLAQFAITFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T198328 NZ_CP096845:1237682-1238056 [Mycobacterium tuberculosis variant bovis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT198328 NZ_CP072689:c2512284-2512218 [Escherichia marmotae]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A7H9K3A2

Antitoxin