Detailed information of TA system TA198314

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 698884..699142
• Replicon: chromosome
• Accession: NZ_CP072689
• Organism: Escherichia marmotae strain YF8

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: J8I93_RS03200
• Protein ID: WP_000809168.1
• Coordinates: 698884..699036 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	699085..699142 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8I93_RS03170	694062..694160	-	99	Protein_611	hypothetical protein	-
J8I93_RS03175	694209..694775	-	567	WP_000528538.1	acetate uptake transporter	-
J8I93_RS03180	694924..695037	-	114	Protein_613	hypothetical protein	-
J8I93_RS03185	695048..695267	-	220	Protein_614	DUF2541 family protein	-
J8I93_RS03190	695644..697560	+	1917	WP_000516135.1	molecular chaperone DnaK	-
J8I93_RS03195	697649..698779	+	1131	WP_001118463.1	molecular chaperone DnaJ	-
J8I93_RS03200	698884..699036	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	699085..699142	+	58	-	-	Antitoxin
J8I93_RS03205	699620..700786	+	1167	WP_061091145.1	Na+/H+ antiporter NhaA	-
J8I93_RS03210	700846..701751	+	906	WP_000062876.1	transcriptional activator NhaR	-
J8I93_RS03215	701854..702117	-	264	WP_001274018.1	30S ribosomal protein S20	-
J8I93_RS03220	702220..702438	+	219	Protein_621	DUF2575 domain-containing protein	-
J8I93_RS03225	702446..703387	+	942	WP_000767344.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T198314 WP_000809168.1 NZ_CP072689:c699036-698884 [Escherichia marmotae]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T198314 NZ_CP096845:c692976-692584 [Mycobacterium tuberculosis variant bovis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT198314 NZ_CP072689:699085-699142 [Escherichia marmotae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin