Detailed information of TA system TA198310

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-OrzO/SymE(toxin)
• Location: 619450..619862
• Replicon: chromosome
• Accession: NZ_CP072689
• Organism: Escherichia marmotae strain YF8

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A370V989
• Locus tag: J8I93_RS02815
• Protein ID: WP_061091158.1
• Coordinates: 619450..619791 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	OrzO
Locus tag	-
Coordinates	619786..619862 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8I93_RS02805 (616863)	616863..617909	-	1047	WP_072274951.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
J8I93_RS02810 (617909)	617909..619288	-	1380	WP_061091159.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
J8I93_RS02815 (619450)	619450..619791	-	342	WP_061091158.1	endoribonuclease SymE	Toxin
- (619786)	619786..619862	+	77	NuclAT_10	-	Antitoxin
- (619786)	619786..619862	+	77	NuclAT_10	-	Antitoxin
- (619786)	619786..619862	+	77	NuclAT_10	-	Antitoxin
- (619786)	619786..619862	+	77	NuclAT_10	-	Antitoxin
- (619786)	619786..619862	+	77	NuclAT_11	-	Antitoxin
- (619786)	619786..619862	+	77	NuclAT_11	-	Antitoxin
- (619786)	619786..619862	+	77	NuclAT_11	-	Antitoxin
- (619786)	619786..619862	+	77	NuclAT_11	-	Antitoxin
J8I93_RS02820 (620019)	620019..621341	-	1323	WP_225996958.1	restriction endonuclease subunit S	-
J8I93_RS02825 (621338)	621338..622918	-	1581	WP_192856150.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	607159..621341	14182

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12312.10 Da
• Isoelectric Point: 7.8219

>T198310 WP_061091158.1 NZ_CP072689:c619791-619450 [Escherichia marmotae]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLESAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T198310 NZ_CP096845:361472-361774 [Mycobacterium tuberculosis variant bovis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Nucleotide

• Length: 77 bp

>AT198310 NZ_CP072689:619786-619862 [Escherichia marmotae]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A370V989

Antitoxin