Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2972011..2972812 Replicon chromosome
Accession NZ_CP072687
Organism Escherichia coli strain YP3

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag J8I95_RS14335 Protein ID WP_000854739.1
Coordinates 2972011..2972391 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag J8I95_RS14340 Protein ID WP_001285482.1
Coordinates 2972438..2972812 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8I95_RS14300 (2967603) 2967603..2968157 - 555 WP_001001921.1 molecular chaperone YcdY -
J8I95_RS14305 (2968181) 2968181..2968918 - 738 WP_000283664.1 zinc-binding phosphatase -
J8I95_RS14310 (2968973) 2968973..2969911 - 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
J8I95_RS14320 (2970381) 2970381..2971224 - 844 Protein_2813 DUF4942 domain-containing protein -
J8I95_RS14325 (2971309) 2971309..2971506 - 198 WP_000772027.1 DUF957 domain-containing protein -
J8I95_RS14330 (2971526) 2971526..2972014 - 489 WP_001054232.1 DUF5983 family protein -
J8I95_RS14335 (2972011) 2972011..2972391 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
J8I95_RS14340 (2972438) 2972438..2972812 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J8I95_RS14345 (2972862) 2972862..2973506 - 645 WP_000086763.1 hypothetical protein -
J8I95_RS14350 (2973525) 2973525..2973746 - 222 WP_000692315.1 DUF987 domain-containing protein -
J8I95_RS14355 (2973809) 2973809..2974285 - 477 WP_001186170.1 RadC family protein -
J8I95_RS14360 (2974301) 2974301..2974774 - 474 WP_000855076.1 antirestriction protein -
J8I95_RS14365 (2975037) 2975037..2975858 - 822 WP_001234710.1 DUF932 domain-containing protein -
J8I95_RS14370 (2976037) 2976037..2976126 - 90 WP_112031555.1 DUF905 family protein -
J8I95_RS14375 (2976269) 2976269..2976724 - 456 WP_000581502.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T198276 WP_000854739.1 NZ_CP072687:c2972391-2972011 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T198276 NZ_CP096844:c1576558-1576157 [Mycobacterium tuberculosis variant bovis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGGCCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT198276 WP_001285482.1 NZ_CP072687:c2972812-2972438 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT198276 NZ_CP096844:c1576812-1576555 [Mycobacterium tuberculosis variant bovis]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References