Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1939460..1940294 Replicon chromosome
Accession NZ_CP072687
Organism Escherichia coli strain YP3

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2T3TJB4
Locus tag J8I95_RS09220 Protein ID WP_000854811.1
Coordinates 1939460..1939837 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2T3TJJ3
Locus tag J8I95_RS09225 Protein ID WP_001285590.1
Coordinates 1939926..1940294 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8I95_RS09180 (1934846) 1934846..1936012 + 1167 WP_000830157.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
J8I95_RS09185 (1936131) 1936131..1936604 + 474 WP_001105395.1 DNA gyrase inhibitor SbmC -
J8I95_RS09190 (1936803) 1936803..1937861 + 1059 WP_001200890.1 FUSC family protein -
J8I95_RS09195 (1938033) 1938033..1938362 + 330 WP_000450409.1 DUF496 family protein -
J8I95_RS09200 (1938463) 1938463..1938597 - 135 WP_001417572.1 EutP/PduV family microcompartment system protein -
J8I95_RS09205 (1938765) 1938765..1938845 + 81 WP_023441679.1 hypothetical protein -
J8I95_RS09210 (1939134) 1939134..1939214 - 81 Protein_1805 hypothetical protein -
J8I95_RS09215 (1939260) 1939260..1939463 - 204 WP_000777677.1 DUF5983 family protein -
J8I95_RS09220 (1939460) 1939460..1939837 - 378 WP_000854811.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
J8I95_RS09225 (1939926) 1939926..1940294 - 369 WP_001285590.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
J8I95_RS09230 (1940368) 1940368..1940589 - 222 WP_000692300.1 DUF987 domain-containing protein -
J8I95_RS09235 (1940658) 1940658..1941134 - 477 WP_001186771.1 RadC family protein -
J8I95_RS09240 (1941150) 1941150..1941629 - 480 WP_000860074.1 antirestriction protein -
J8I95_RS09245 (1941711) 1941711..1942532 - 822 WP_089582437.1 DUF932 domain-containing protein -
J8I95_RS09250 (1942753) 1942753..1943163 - 411 WP_000846713.1 hypothetical protein -
J8I95_RS09255 (1943179) 1943179..1943862 - 684 WP_000775499.1 hypothetical protein -
J8I95_RS09260 (1943998) 1943998..1945068 - 1071 WP_000102629.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gtrB / gtrA 1923101..1945970 22869


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14041.14 Da        Isoelectric Point: 7.8839

>T198265 WP_000854811.1 NZ_CP072687:c1939837-1939460 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Download         Length: 378 bp

>T198265 NZ_CP096844:c756398-756090 [Mycobacterium tuberculosis variant bovis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13608.50 Da        Isoelectric Point: 6.6242

>AT198265 WP_001285590.1 NZ_CP072687:c1940294-1939926 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLYSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT198265 NZ_CP096844:c756630-756385 [Mycobacterium tuberculosis variant bovis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T3TJB4

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3TJJ3

References