Detailed information of TA system TA198258

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 44436..45234
• Replicon: chromosome
• Accession: NZ_CP072687
• Organism: Escherichia coli strain YP3

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: J8I95_RS00240
• Protein ID: WP_016238198.1
• Coordinates: 44436..44813 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A067H947
• Locus tag: J8I95_RS00245
• Protein ID: WP_001285415.1
• Coordinates: 44860..45234 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8I95_RS00205 (39570)	39570..39863	-	294	WP_001297978.1	protein YicS	-
J8I95_RS00210 (40085)	40085..40903	+	819	WP_000779409.1	lipoprotein NlpA	-
J8I95_RS00215 (40907)	40907..41830	-	924	WP_001445306.1	carboxylate/amino acid/amine transporter	-
J8I95_RS00220 (41997)	41997..42494	-	498	WP_000509810.1	hypothetical protein	-
J8I95_RS00225 (43090)	43090..43932	-	843	WP_001521669.1	DUF4942 domain-containing protein	-
J8I95_RS00230 (44017)	44017..44214	-	198	WP_086795284.1	DUF957 domain-containing protein	-
J8I95_RS00235 (44290)	44290..44439	-	150	Protein_46	DUF5983 family protein	-
J8I95_RS00240 (44436)	44436..44813	-	378	WP_016238198.1	TA system toxin CbtA family protein	Toxin
J8I95_RS00245 (44860)	44860..45234	-	375	WP_001285415.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
J8I95_RS00250 (45314)	45314..45535	-	222	WP_000692328.1	DUF987 domain-containing protein	-
J8I95_RS00255 (45604)	45604..46080	-	477	WP_016238197.1	RadC family protein	-
J8I95_RS00260 (46096)	46096..46581	-	486	WP_182487914.1	antirestriction protein	-
J8I95_RS00265 (46673)	46673..47491	-	819	WP_021546487.1	DUF932 domain-containing protein	-
J8I95_RS00270 (47581)	47581..47814	-	234	WP_001278287.1	DUF905 family protein	-
J8I95_RS00275 (47820)	47820..48497	-	678	WP_001097301.1	hypothetical protein	-
J8I95_RS00280 (48645)	48645..49325	-	681	WP_001282919.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14206.16 Da
• Isoelectric Point: 6.9576

>T198258 WP_016238198.1 NZ_CP072687:c44813-44436 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTHSQLINSIDILRARRATGLMTRDNYRMVNDISQGKHPEAKQ

Nucleotide

• Length: 378 bp

>T198258 NZ_CP096844:c696113-695721 [Mycobacterium tuberculosis variant bovis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13663.32 Da
• Isoelectric Point: 5.8640

>AT198258 WP_001285415.1 NZ_CP072687:c45234-44860 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Nucleotide

• Length: 375 bp

>AT198258 NZ_CP096844:c696367-696110 [Mycobacterium tuberculosis variant bovis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A067H947