Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1967778..1968609 Replicon chromosome
Accession NZ_CP072686
Organism Escherichia coli strain FP4

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag J8I94_RS09490 Protein ID WP_000854814.1
Coordinates 1967778..1968152 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A366YXM1
Locus tag J8I94_RS09495 Protein ID WP_001518724.1
Coordinates 1968241..1968609 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8I94_RS09450 (1963174) 1963174..1964340 + 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
J8I94_RS09455 (1964459) 1964459..1964932 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
J8I94_RS09460 (1965130) 1965130..1966188 + 1059 WP_001200894.1 FUSC family protein -
J8I94_RS09465 (1966360) 1966360..1966689 + 330 WP_000450409.1 DUF496 family protein -
J8I94_RS09470 (1966790) 1966790..1967113 - 324 WP_223216378.1 EutP/PduV family microcompartment system protein -
J8I94_RS09475 (1967092) 1967092..1967172 + 81 WP_023441679.1 hypothetical protein -
J8I94_RS09480 (1967461) 1967461..1967541 - 81 Protein_1859 hypothetical protein -
J8I94_RS09485 (1967587) 1967587..1967781 - 195 WP_000988601.1 DUF5983 family protein -
J8I94_RS09490 (1967778) 1967778..1968152 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
J8I94_RS09495 (1968241) 1968241..1968609 - 369 WP_001518724.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
J8I94_RS09500 (1968683) 1968683..1968904 - 222 WP_000692323.1 DUF987 domain-containing protein -
J8I94_RS09505 (1968967) 1968967..1969443 - 477 WP_001186773.1 RadC family protein -
J8I94_RS09510 (1969459) 1969459..1969932 - 474 WP_000855075.1 antirestriction protein -
J8I94_RS09515 (1970195) 1970195..1971016 - 822 WP_001234710.1 DUF932 domain-containing protein -
J8I94_RS09520 (1971237) 1971237..1971647 - 411 WP_000846705.1 hypothetical protein -
J8I94_RS09525 (1971663) 1971663..1972316 - 654 WP_001535423.1 hypothetical protein -
J8I94_RS09530 (1972409) 1972409..1973586 + 1178 WP_152895938.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T198239 WP_000854814.1 NZ_CP072686:c1968152-1967778 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T198239 NZ_CP096843:2893684-2894124 [Mycobacterium tuberculosis variant bovis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13441.24 Da        Isoelectric Point: 4.7594

>AT198239 WP_001518724.1 NZ_CP072686:c1968609-1968241 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLSSDADAYPLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLACEADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT198239 NZ_CP096843:2893410-2893697 [Mycobacterium tuberculosis variant bovis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A366YXM1

References