Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3630682..3632380 Replicon chromosome
Accession NZ_CP072564
Organism Escherichia coli strain WG5::PA2

Toxin (Protein)


Gene name mosT Uniprot ID A0A3Y1KBU9
Locus tag J8F87_RS17475 Protein ID WP_047085429.1
Coordinates 3630682..3631611 (-) Length 310 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag J8F87_RS17480 Protein ID WP_172808160.1
Coordinates 3631598..3632380 (-) Length 261 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8F87_RS17450 (3626110) 3626110..3627618 + 1509 WP_032206693.1 group II intron reverse transcriptase/maturase -
J8F87_RS17455 (3627702) 3627702..3628181 + 480 Protein_3428 IS3 family transposase -
J8F87_RS17460 (3628220) 3628220..3628399 - 180 Protein_3429 hypothetical protein -
J8F87_RS17465 (3628565) 3628565..3629287 - 723 WP_081508859.1 SDR family oxidoreductase -
J8F87_RS17470 (3629386) 3629386..3630285 + 900 WP_000687182.1 LysR family transcriptional regulator -
J8F87_RS17475 (3630682) 3630682..3631611 - 930 WP_047085429.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
J8F87_RS17480 (3631598) 3631598..3632380 - 783 WP_172808160.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
J8F87_RS17485 (3632664) 3632664..3634331 + 1668 WP_236941917.1 type I restriction endonuclease -
J8F87_RS17490 (3634394) 3634394..3635556 + 1163 WP_085947598.1 IS3-like element IS3 family transposase -
J8F87_RS17495 (3635553) 3635553..3635852 - 300 WP_236941918.1 hypothetical protein -
J8F87_RS17500 (3635977) 3635977..3636674 + 698 WP_223293341.1 IS1-like element IS1B family transposase -
J8F87_RS17505 (3636691) 3636691..3636894 - 204 Protein_3438 DUF3987 domain-containing protein -
J8F87_RS17510 (3636953) 3636953..3637048 + 96 WP_211180486.1 putative translational regulatory protein ArgL -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3622952..3636674 13722


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 310 a.a.        Molecular weight: 34960.38 Da        Isoelectric Point: 7.3232

>T198067 WP_047085429.1 NZ_CP072564:c3631611-3630682 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNSK
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMSVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKRNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVSKLERVLEQYS

Download         Length: 930 bp

>T198067 NZ_CP096840:2837567-2837944 [Mycobacterium tuberculosis variant bovis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 261 a.a.        Molecular weight: 29183.36 Da        Isoelectric Point: 8.5995

>AT198067 WP_172808160.1 NZ_CP072564:c3632380-3631598 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKSVRVAGLT
SLALQGHAHYTEPGRPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVTPFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGSGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Download         Length: 783 bp

>AT198067 NZ_CP096840:2837313-2837570 [Mycobacterium tuberculosis variant bovis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3Y1KBU9


Antitoxin

Source ID Structure

References