Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tad-ata/COG5606-COG4679 |
| Location | 2800460..2801153 | Replicon | chromosome |
| Accession | NZ_CP072559 | ||
| Organism | Pseudomonas sp. BYT-1 | ||
Toxin (Protein)
| Gene name | tad | Uniprot ID | N2IHR9 |
| Locus tag | J5X93_RS12850 | Protein ID | WP_003151133.1 |
| Coordinates | 2800460..2800837 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | ata | Uniprot ID | N2IIN5 |
| Locus tag | J5X93_RS12855 | Protein ID | WP_001172026.1 |
| Coordinates | 2800818..2801153 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J5X93_RS12810 (J5X93_12765) | 2795797..2796003 | + | 207 | Protein_2531 | Tn3 family transposase | - |
| J5X93_RS12815 (J5X93_12770) | 2796039..2796476 | - | 438 | Protein_2532 | DNA-binding protein | - |
| J5X93_RS12820 (J5X93_12775) | 2796656..2797633 | + | 978 | WP_250033546.1 | site-specific integrase | - |
| J5X93_RS12825 (J5X93_12780) | 2797662..2798231 | - | 570 | WP_250033550.1 | DUF4946 domain-containing protein | - |
| J5X93_RS12830 (J5X93_12785) | 2798218..2798736 | - | 519 | WP_045665860.1 | ATP-dependent zinc protease | - |
| J5X93_RS12835 (J5X93_12790) | 2798830..2799090 | - | 261 | WP_250033552.1 | hypothetical protein | - |
| J5X93_RS12840 (J5X93_12795) | 2799178..2800002 | - | 825 | Protein_2537 | cation diffusion facilitator family transporter | - |
| J5X93_RS12845 (J5X93_12800) | 2800173..2800352 | + | 180 | Protein_2538 | MerR family transcriptional regulator | - |
| J5X93_RS12850 (J5X93_12805) | 2800460..2800837 | + | 378 | WP_003151133.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J5X93_RS12855 (J5X93_12810) | 2800818..2801153 | + | 336 | WP_001172026.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| J5X93_RS12860 (J5X93_12815) | 2801168..2801503 | + | 336 | WP_000741275.1 | hypothetical protein | - |
| J5X93_RS12865 (J5X93_12820) | 2801527..2801853 | + | 327 | WP_000091614.1 | hypothetical protein | - |
| J5X93_RS12870 (J5X93_12825) | 2801869..2802210 | + | 342 | WP_025999701.1 | hypothetical protein | - |
| J5X93_RS12875 (J5X93_12830) | 2802250..2803518 | + | 1269 | Protein_2544 | Tn3 family transposase | - |
| J5X93_RS12880 (J5X93_12835) | 2803515..2803955 | - | 441 | WP_250035703.1 | DUF1924 domain-containing protein | - |
| J5X93_RS12885 (J5X93_12840) | 2804096..2805691 | + | 1596 | WP_250035718.1 | 2Fe-2S iron-sulfur cluster-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | pvdM / pvdO | 2734028..3275925 | 541897 | |
| - | flank | IS/Tn | - | - | 2795818..2796003 | 185 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13705.78 Da Isoelectric Point: 9.4693
>T198044 WP_003151133.1 NZ_CP072559:2800460-2800837 [Pseudomonas sp. BYT-1]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH
Download Length: 378 bp
>T198044 NZ_CP096840:c1229671-1229360 [Mycobacterium tuberculosis variant bovis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG
Antitoxin
Download Length: 112 a.a. Molecular weight: 12201.39 Da Isoelectric Point: 10.6058
>AT198044 WP_001172026.1 NZ_CP072559:2800818-2801153 [Pseudomonas sp. BYT-1]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA
Download Length: 336 bp
>AT198044 NZ_CP096840:c1229991-1229671 [Mycobacterium tuberculosis variant bovis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A024ELN5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A024EKI7 |