Detailed information of TA system TA197311

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 504780..505359
• Replicon: chromosome
• Accession: NZ_CP072116
• Organism: Staphylococcus aureus strain TCH32929

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: J6L63_RS02740
• Protein ID: WP_001025401.1
• Coordinates: 504780..505025 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	504994..505359 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6L63_RS02690 (501030)	501030..501644	+	615	WP_000191466.1	hypothetical protein	-
J6L63_RS02695 (501641)	501641..501787	-	147	WP_001795334.1	hypothetical protein	-
J6L63_RS02700 (501824)	501824..502006	-	183	WP_000705240.1	hypothetical protein	-
J6L63_RS02705 (502076)	502076..502762	-	687	WP_000177667.1	XRE family transcriptional regulator	-
J6L63_RS02710 (502959)	502959..503171	+	213	WP_260833636.1	helix-turn-helix transcriptional regulator	-
J6L63_RS02715 (503219)	503219..503662	+	444	WP_000435357.1	hypothetical protein	-
J6L63_RS02720 (503677)	503677..503826	+	150	WP_000771849.1	hypothetical protein	-
J6L63_RS02725 (503867)	503867..504079	-	213	WP_000362644.1	hypothetical protein	-
J6L63_RS02730 (504149)	504149..504346	+	198	WP_001148860.1	hypothetical protein	-
J6L63_RS02735 (504333)	504333..504713	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
J6L63_RS02740 (504780)	504780..505025	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
J6L63_RS02745 (504994)	504994..505359	-	366	WP_001128433.1	hypothetical protein	Antitoxin
J6L63_RS02750 (505414)	505414..505629	+	216	WP_001097552.1	hypothetical protein	-
J6L63_RS02755 (505654)	505654..505917	+	264	WP_001124157.1	helix-turn-helix domain-containing protein	-
J6L63_RS02760 (505930)	505930..506091	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
J6L63_RS02765 (506170)	506170..506493	+	324	WP_000174998.1	hypothetical protein	-
J6L63_RS02770 (506508)	506508..506870	+	363	WP_000985972.1	hypothetical protein	-
J6L63_RS02775 (506867)	506867..508033	+	1167	WP_000762530.1	DUF2800 domain-containing protein	-
J6L63_RS02780 (508059)	508059..508616	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T197311 WP_001025401.1 NZ_CP072116:504780-505025 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T197311 NZ_CP095924:183447-183824 [Pseudomonas aeruginosa]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT197311 NZ_CP072116:c505359-504994 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin