Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4881502..4882333 Replicon chromosome
Accession NZ_CP071711
Organism Escherichia coli strain EC20017429

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JQM62_RS24000 Protein ID WP_000854814.1
Coordinates 4881502..4881876 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag JQM62_RS24005 Protein ID WP_001285585.1
Coordinates 4881965..4882333 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQM62_RS23960 (4876898) 4876898..4878064 + 1167 WP_000830150.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
JQM62_RS23965 (4878183) 4878183..4878656 + 474 WP_001105389.1 DNA gyrase inhibitor SbmC -
JQM62_RS23970 (4878854) 4878854..4879912 + 1059 WP_001200891.1 FUSC family protein -
JQM62_RS23975 (4880084) 4880084..4880413 + 330 WP_000450409.1 DUF496 family protein -
JQM62_RS23980 (4880514) 4880514..4880648 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
JQM62_RS23985 (4880768) 4880768..4880896 + 129 Protein_4699 transposase domain-containing protein -
JQM62_RS23990 (4881185) 4881185..4881265 - 81 Protein_4700 hypothetical protein -
JQM62_RS23995 (4881311) 4881311..4881505 - 195 WP_000988600.1 DUF5983 family protein -
JQM62_RS24000 (4881502) 4881502..4881876 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
JQM62_RS24005 (4881965) 4881965..4882333 - 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
JQM62_RS24010 (4882407) 4882407..4882628 - 222 WP_000692323.1 DUF987 domain-containing protein -
JQM62_RS24015 (4882691) 4882691..4883167 - 477 WP_001186726.1 RadC family protein -
JQM62_RS24020 (4883183) 4883183..4883662 - 480 WP_000860087.1 antirestriction protein -
JQM62_RS24025 (4883744) 4883744..4884562 - 819 WP_001234629.1 DUF932 domain-containing protein -
JQM62_RS24030 (4884662) 4884662..4884895 - 234 WP_001119729.1 DUF905 family protein -
JQM62_RS24035 (4884974) 4884974..4885429 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T196773 WP_000854814.1 NZ_CP071711:c4881876-4881502 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T196773 NZ_CP095412:2892015-2892359 [Blastococcus sp. PRF04-17]
GTGATCCAACGGGGCCAGGTCCGCTGGGCAGATCTGGGGCCACCCCGCGGGAGCGCACCCGCACTGCGGCGCCCGGTGCT
CGTGGTGCAGATCGACCGGCTGTCCCGCTCTCGGATCGCGACGGTTGCGGTCGTGATCCTGACGTCGAATCTGCGCCTGG
CTGAGGTGCCGGGCAACGTCCTCGTGAAGCCGGAGGACTCCGGCCTGCCCGACCCTTCGGTCGTCAATGTGAGCCAGCTG
GTCTCGGTGGACAAGGCATTCCTGGACGACCAACCTCGAGGTCTGCTGCCGCTGGACGTCATGGCCCGCGTCGATGCCGG
CCTGCGGCTGGTGCTCGGGCTCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT196773 WP_001285585.1 NZ_CP071711:c4882333-4881965 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT196773 NZ_CP095412:2891752-2892018 [Blastococcus sp. PRF04-17]
GTGAAGACGGCCATCTCCATTCCGGACCACACCTTCGCCGAAGCCGACCGCCGTGCCCGCGAGTTGGGGCTCAACCGCTC
GCAATTCGTCACCAGGGCGATCGAGAGGTACCTGAACGAGTTGGCCGAAGGCGACGACCTCACCGACCGCATCAACGCGG
CCCTGGACGCTGCCGGTCCGGAGGACCCCGACGACATCGCCGTTCGCAAGGCGGCCACGCGGGCAGCCTTCGCCCGGCTC
GATGCCGAGGACGGCGGCTGGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References