Detailed information of TA system TA196756

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 897419..897897
• Replicon: chromosome
• Accession: NZ_CP071711
• Organism: Escherichia coli strain EC20017429

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: JQM62_RS04795
• Protein ID: WP_001303876.1
• Coordinates: 897610..897897 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: JQM62_RS04790
• Protein ID: WP_000536233.1
• Coordinates: 897419..897610 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQM62_RS04755 (892799)	892799..893569	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
JQM62_RS04760 (893651)	893651..894337	-	687	WP_000788749.1	ATP-binding protein	-
JQM62_RS04765 (894344)	894344..895459	-	1116	WP_001205820.1	hypothetical protein	-
JQM62_RS04770 (895538)	895538..895993	+	456	WP_000273724.1	hypothetical protein	-
JQM62_RS04775 (896200)	896200..896625	-	426	WP_000693855.1	toxin YdaT family protein	-
JQM62_RS04780 (896609)	896609..896881	-	273	WP_000887453.1	YdaS family helix-turn-helix protein	-
JQM62_RS04785 (896990)	896990..897391	+	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
JQM62_RS04790 (897419)	897419..897610	+	192	WP_000536233.1	hypothetical protein	Antitoxin
JQM62_RS04795 (897610)	897610..897897	+	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JQM62_RS04800 (898174)	898174..898329	+	156	WP_000379575.1	DUF1391 family protein	-
JQM62_RS30040 (898331)	898331..898459	+	129	WP_000344963.1	protein YdfB	-
JQM62_RS04805 (898471)	898471..898860	+	390	WP_000394513.1	hypothetical protein	-
JQM62_RS04810 (899047)	899047..899232	-	186	WP_001133046.1	hypothetical protein	-
JQM62_RS04820 (901073)	901073..901261	+	189	WP_000413705.1	cell division inhibition protein DicB	-
JQM62_RS04825 (901258)	901258..901449	+	192	WP_001098307.1	DUF1482 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T196756 WP_001303876.1 NZ_CP071711:897610-897897 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T196756 NZ_CP095384:c2490499-2490116 [Lacticaseibacillus rhamnosus]
ATGGATGTAACAGTCAAACGCGGGGATGTATTTTTCGCCGATTTATCGCCGGTTGTCGGGTCGGAACAAGGCGGCAACCG
GCCCGTACTTATTATTCAAAATAACGTTGGCAATCACTATAGTCCCACCGTCATTGTGGCTGCCATTACCTCCAAAATCC
AAAAACCCAAAATGCCCACCCATGTCGGTTTGCGCGCCAAGCAAGACGGGGTTGAGCGTAATTCAGTCATTTTGCTTGAA
CAGATTCGTACAATTGATAAGCAACGGCTACAGGCACGCGTTACCGCTCTTTCAAGTGCCAAAATGGCAGCGGTGGATCG
GGCACTGGCGATATCGGTCGGACTCGTCAGCTTGCCTAAGCCGAAAACATATAATAAAAACTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT196756 WP_000536233.1 NZ_CP071711:897419-897610 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT196756 NZ_CP095384:c2490767-2490519 [Lacticaseibacillus rhamnosus]
ATGAAGAAGGAAACGTCAGTAACGGTCGCGCTTGACAGTGCTATCAAAGCGCGTTTGGATGCCTATTGCGAGTTGAATGA
TATGGGTGTTCAGGATGTCATTACTGAAGCAGTGGCGAAGTTTTTGCAGTCACAAGCACCTGAGATCAATCAGTTGATTT
CAGGCTATGTGGCAATGGGACAAATCAATACGGAAATCAGCCATGCTTTCTCCGCCTGCGAAAGTGAGGCATACGCCCAT
ATTCGATAA