Detailed information of TA system TA196601

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1363802..1364438
• Replicon: chromosome
• Accession: NZ_CP071602
• Organism: Bordetella parapertussis strain CIDM-BPP2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q7W5Z1
• Locus tag: J3Q23_RS06390
• Protein ID: WP_010928914.1
• Coordinates: 1364256..1364438 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q7W5Z0
• Locus tag: J3Q23_RS06385
• Protein ID: WP_010928915.1
• Coordinates: 1363802..1364194 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3Q23_RS06360	1359458..1359884	-	427	Protein_1251	OB-fold domain-containing protein	-
J3Q23_RS06365	1359888..1361060	-	1173	WP_010928918.1	thiolase domain-containing protein	-
J3Q23_RS06370	1361127..1361486	-	360	WP_010928917.1	hypothetical protein	-
J3Q23_RS06375	1361521..1362495	-	975	WP_010928916.1	tripartite tricarboxylate transporter substrate binding protein	-
J3Q23_RS06380	1362620..1363529	+	910	Protein_1255	LysR family transcriptional regulator	-
J3Q23_RS06385	1363802..1364194	-	393	WP_010928915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J3Q23_RS06390	1364256..1364438	-	183	WP_010928914.1	type II toxin-antitoxin system HicA family toxin	Toxin
J3Q23_RS06395	1364987..1366207	-	1221	WP_010928912.1	ISL3-like element IS1001 family transposase	-
J3Q23_RS06405	1366782..1367969	-	1188	WP_010928911.1	MFS transporter	-
J3Q23_RS06410	1368187..1368864	-	678	WP_010928910.1	HAD-IA family hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1364987..1366207	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6572.69 Da
• Isoelectric Point: 10.9062

>T196601 WP_010928914.1 NZ_CP071602:c1364438-1364256 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T196601 NZ_CP095177:c2312125-2311640 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCGCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCATTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCACTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTTGATGTCTCGTTACGCGGAAACGGGCTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCT
CAGTAG

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14058.82 Da
• Isoelectric Point: 4.2876

>AT196601 WP_010928915.1 NZ_CP071602:c1364194-1363802 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT196601 NZ_CP095177:c2312379-2312113 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACAGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA

Structures

Toxin

• AlphaFold DB: Q7W5Z1

Antitoxin

• AlphaFold DB: Q7W5Z0