Detailed information of TA system TA196597

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF2/-
• Location: 2906958..2907257
• Replicon: chromosome
• Accession: NZ_CP071594
• Organism: Staphylococcus aureus strain PNID0137

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: J3R87_RS14555
• Protein ID: WP_011447039.1
• Coordinates: 2907081..2907257 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2906958..2907015 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3R87_RS14510	2901997..2902194	+	198	WP_000239619.1	hypothetical protein	-
J3R87_RS14515	2902566..2902745	+	180	WP_000669789.1	hypothetical protein	-
J3R87_RS14520	2903056..2903316	+	261	WP_001791826.1	hypothetical protein	-
J3R87_RS14525	2903369..2903719	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
J3R87_RS14530	2904230..2904565	-	336	Protein_2840	SH3 domain-containing protein	-
J3R87_RS14535	2905166..2905657	-	492	WP_000920041.1	staphylokinase	-
J3R87_RS14540	2905848..2906603	-	756	WP_000861038.1	CHAP domain-containing protein	-
J3R87_RS14545	2906615..2906869	-	255	WP_000611512.1	phage holin	-
J3R87_RS14550	2906921..2907028	+	108	WP_031790389.1	hypothetical protein	-
-	2906950..2907089	+	140	NuclAT_1	-	-
-	2906950..2907089	+	140	NuclAT_1	-	-
-	2906950..2907089	+	140	NuclAT_1	-	-
-	2906950..2907089	+	140	NuclAT_1	-	-
-	2906958..2907015	+	58	-	-	Antitoxin
J3R87_RS14555	2907081..2907257	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
J3R87_RS14560	2907407..2907703	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
J3R87_RS14565	2907761..2908048	-	288	WP_001040261.1	hypothetical protein	-
J3R87_RS14570	2908095..2908247	-	153	WP_001153681.1	hypothetical protein	-
J3R87_RS14575	2908237..2912022	-	3786	WP_073392894.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / sak	2897594..2914177	16583

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T196597 WP_011447039.1 NZ_CP071594:c2907257-2907081 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T196597 NZ_CP095172:37614-38117 [Enterobacter roggenkampii]
ATGTTTTCAGCACAAGCCGTATACGATTTTTCGGGCTTCGACTGCGGCGAACCATCTCTGAATGATTTCCTGCAAAACCG
CCTGGTACAGCAACACAACGGGCGTATATTACGTGGCTACCTGCTTCTTACCAAAGATCCGGTGCCGAAAGTTAAGGGTT
TTTACACGCTATCCGGGAGTTGTTTTGCAAGACAGACGCTACCATCGAACACCCAGAAGCGGAAAATCCCCTACCCAGAT
GCTCCCAGCGTTACGCTTGGCCGTCTGGCAATAGATATCAGCCTACAGAAACAAGGCTACGGGGAGGTTCTCGTAACACA
CGCTTTGAAGGTTGTTTACCAGGCTTCTCGCGCAGTAGGCATATACGCTTTGTTTGTGGATGCACTAAACCAAAGCGCAA
TGCAGTTCTATCAGAAGTTTGGCTTCATCCCTTTGACGGGAGCGAATGCCAACTCGCTTTTCTACCCCACGAAAAGCATT
GAAGAGCTGTTTGAAACAGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT196597 NZ_CP071594:2906958-2907015 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• PDB: 7NS1

Antitoxin