Detailed information of TA system TA196565

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 425694..426210
• Replicon: chromosome
• Accession: NZ_CP071586
• Organism: Pseudomonas germanica strain FIT28

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A2S9B813
• Locus tag: J0G10_RS01855
• Protein ID: WP_064389059.1
• Coordinates: 425929..426210 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J0G10_RS01850
• Protein ID: WP_220557273.1
• Coordinates: 425694..425939 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J0G10_RS01815 (J0G10_01815)	420897..421502	+	606	WP_220557268.1	adenylyl-sulfate kinase	-
J0G10_RS01820 (J0G10_01820)	421499..422284	+	786	WP_220557269.1	aspartyl/asparaginyl beta-hydroxylase domain-containing protein	-
J0G10_RS01825 (J0G10_01825)	422272..423255	+	984	WP_220557270.1	sulfotransferase family protein	-
J0G10_RS01830 (J0G10_01830)	423296..424054	-	759	WP_038367334.1	slipin family protein	-
J0G10_RS01835 (J0G10_01835)	424057..424587	-	531	WP_220557271.1	NfeD family protein	-
J0G10_RS01840 (J0G10_01840)	424763..425224	+	462	WP_095047033.1	YbaK/EbsC family protein	-
J0G10_RS01845 (J0G10_01845)	425354..425599	+	246	WP_220557272.1	DUF2789 domain-containing protein	-
J0G10_RS01850 (J0G10_01850)	425694..425939	+	246	WP_220557273.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J0G10_RS01855 (J0G10_01855)	425929..426210	+	282	WP_064389059.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J0G10_RS01860 (J0G10_01860)	426354..426782	+	429	WP_093440308.1	winged helix DNA-binding protein	-
J0G10_RS01865 (J0G10_01865)	426779..428842	+	2064	WP_095047036.1	FUSC family protein	-
J0G10_RS01870 (J0G10_01870)	428839..429048	+	210	WP_007917703.1	DUF1656 domain-containing protein	-
J0G10_RS01875 (J0G10_01875)	429045..429947	+	903	WP_064389057.1	HlyD family secretion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10817.72 Da
• Isoelectric Point: 10.6086

>T196565 WP_064389059.1 NZ_CP071586:425929-426210 [Pseudomonas germanica]
MTYKLEFLPSAHKEWNKLGHTLREQFKKKLGERLKLPRVSADALHGMPDCYKIKLKASGYRLVYQVIDERVVVSVVAVGK
RERSSVYENAKKR

Nucleotide

• Length: 282 bp

>T196565 NZ_CP095162:919248-920093 [Streptococcus suis]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTCTTGAAGTGATTTTGAAAAAATTAAGTCAGAGTACCTATTCAAATCACTATATATTCAAAGGAGGATTCCTAC
TGTCAAATGTTATCGGAGTTGAATCTCGTAGCACGGTTGATATTGATTTTTTGTTCCATCAAATAACACTTTCAGAAGAT
ACTGTGAAGCAGCAACTCAAGGAAATTTTAGCAGATTCAAAAGAAGGTATTTCTTTCACAATTCAATCTATCACAGCAAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACCATTTTGTGCCAAATTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAGAAACTTCAAACCATCTATTCACGCAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAGAAAGAAGACATTGACTTCATTCAGTTGAAAAATGCCTGTC
AGAGAACATTTACATATCGCGAAACAGAACTCGATTTTGCAAAGATTATTGAACTACTCGAGAGATTCAAATCTGATCCT
ACTCAGAATCAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTTATAACAGTACTCATTTCTATAAATTCTGATTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8753.03 Da
• Isoelectric Point: 4.4988

>AT196565 WP_220557273.1 NZ_CP071586:425694-425939 [Pseudomonas germanica]
MQSVLADMAVSVSELKKNPSTVLSGAHGGAVAVLNHNRVMGYMVPADVYEAMMERLDDLELAEIVRARSHETPISVSLDD
L

Nucleotide

• Length: 246 bp

>AT196565 NZ_CP095162:918661-919251 [Streptococcus suis]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGCATTATCACCTATAAAGATTGTAAAGCTCTAAA
GATTCCAACAATATATTTGACAAGACTAGAAAAAGAAGGGATTCTATACCGCGTCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGACGAATACTACTTCTTTCAGTACCGTTATCCCAAGGCTATTTTCTCTTATATCTCAGCGCTTTACCTG
CAACAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGCTACCGTTTTAATACTCCTCCAGCAAA
TCTGAACATTCATTCCGTTTCTAAGGAATATAGCGAACTGGGAATTACACTTGTAAAAACCCCTATGGGAAACGAGGTAA
GTGTGTATGATTTAGAACGTATTATCTGTGATTTTGTGATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACATTACGGAAACTATTCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACTTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Structures

Toxin

• AlphaFold DB: A0A2S9B813