Detailed information of TA system TA196251

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 441544..442139
• Replicon: chromosome
• Accession: NZ_CP071383
• Organism: Leclercia sp. 4-9-1-25

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: JZ655_RS02065
• Protein ID: WP_207292876.1
• Coordinates: 441789..442139 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: -
• Locus tag: JZ655_RS02060
• Protein ID: WP_040077462.1
• Coordinates: 441544..441795 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZ655_RS02050	437197..440973	+	3777	WP_207292875.1	translocation/assembly module TamB domain-containing protein	-
JZ655_RS02055	440976..441320	+	345	WP_040077463.1	gamma-glutamylcyclotransferase	-
JZ655_RS02060	441544..441795	+	252	WP_040077462.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
JZ655_RS02065	441789..442139	+	351	WP_207292876.1	type II toxin-antitoxin system ChpB family toxin	Toxin
JZ655_RS02070	442176..443759	-	1584	WP_207292877.1	HAMP domain-containing protein	-
JZ655_RS02075	444014..444544	-	531	WP_040077459.1	inorganic diphosphatase	-
JZ655_RS02080	444854..445810	+	957	WP_046886414.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (9-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12425.26 Da
• Isoelectric Point: 5.0196

>T196251 WP_207292876.1 NZ_CP071383:441789-442139 [Leclercia sp. 4-9-1-25]
MVRALTYDRGDIVLVNFSPANGHEQQGAGRPALVLSLSTFNQTGMVLVAPITQGGSYARYAGFAVPVSCEEGDVQGAVLV
NQLRMMDLHARQAKKIAIATDEVVEDALLRLQAIID

Nucleotide

• Length: 351 bp

>T196251 NZ_CP095023:2866682-2867095 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9096.50 Da
• Isoelectric Point: 4.4384

>AT196251 WP_040077462.1 NZ_CP071383:441544-441795 [Leclercia sp. 4-9-1-25]
MRITIKKWGNSAGVIIPGAIMKELNMQVGQSMEAQVVDNQVVLKPLSKRYTLEELLAQCDPNAAPATEDELWGNAGPMGN
EVW

Nucleotide

• Length: 252 bp

>AT196251 NZ_CP095023:2867134-2867391 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA