Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 802844..803394 Replicon chromosome
Accession NZ_CP071375
Organism Escherichia coli strain E105

Toxin (Protein)


Gene name ccdB Uniprot ID D3H432
Locus tag J0O73_RS03860 Protein ID WP_001160975.1
Coordinates 803080..803394 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag J0O73_RS03855 Protein ID WP_000125567.1
Coordinates 802844..803077 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0O73_RS03830 797914..798201 + 288 WP_000203741.1 ferredoxin-like protein FixX -
J0O73_RS03835 798260..799591 + 1332 WP_001183198.1 MFS transporter -
J0O73_RS03840 799702..800232 + 531 WP_000600718.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
J0O73_RS03845 800225..802087 + 1863 WP_000377117.1 glutathione-regulated potassium-efflux system protein KefC -
J0O73_RS03850 802279..802758 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
J0O73_RS03855 802844..803077 + 234 WP_000125567.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
J0O73_RS03860 803080..803394 + 315 WP_001160975.1 CcdB family protein Toxin
J0O73_RS03865 803391..804239 - 849 WP_000257188.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
J0O73_RS03870 804246..804623 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
J0O73_RS03875 804626..805447 - 822 WP_096220318.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
J0O73_RS03880 805444..806433 - 990 WP_053883425.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
J0O73_RS03885 806433..807719 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.76 Da        Isoelectric Point: 9.8517

>T196215 WP_001160975.1 NZ_CP071375:803080-803394 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T196215 NZ_CP095023:c641964-641551 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8544.55 Da        Isoelectric Point: 5.8147

>AT196215 WP_000125567.1 NZ_CP071375:802844-803077 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSEEYRSF

Download         Length: 234 bp

>AT196215 NZ_CP095023:c642227-641961 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References