Detailed information of TA system TA196161

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-couple_hipB
• Location: 1040511..1041754
• Replicon: chromosome
• Accession: NZ_CP071305
• Organism: Streptococcus suis strain SC183

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: G7SEB4
• Locus tag: JZY07_RS05215
• Protein ID: WP_001235242.1
• Coordinates: 1040987..1041754 (+)
• Length: 256 a.a.

Antitoxin (Protein)

• Gene name: sezA
• Uniprot ID: -
• Locus tag: JZY07_RS05210
• Protein ID: WP_000578719.1
• Coordinates: 1040511..1040987 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZY07_RS05180	1035628..1036524	-	897	WP_001809760.1	ParA family protein	-
JZY07_RS05185	1036599..1038293	+	1695	WP_014636621.1	recombinase family protein	-
JZY07_RS05190	1038357..1039433	+	1077	WP_024400599.1	toprim domain-containing protein	-
JZY07_RS05195	1039487..1039714	+	228	WP_000110922.1	hypothetical protein	-
JZY07_RS05200	1039711..1040100	+	390	WP_024400598.1	chemotaxis protein	-
JZY07_RS05205	1040151..1040441	+	291	WP_000667951.1	hypothetical protein	-
JZY07_RS05210	1040511..1040987	+	477	WP_000578719.1	helix-turn-helix domain-containing protein	Antitoxin
JZY07_RS05215	1040987..1041754	+	768	WP_001235242.1	zeta toxin family protein	Toxin
JZY07_RS05220	1041833..1042243	+	411	Protein_985	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
JZY07_RS05225	1042259..1043122	+	864	WP_002294505.1	aminoglycoside nucleotidyltransferase ANT(6)-Ia	-
JZY07_RS05230	1043166..1043693	+	528	WP_002294507.1	adenine phosphoribosyltransferase	-
JZY07_RS05235	1043825..1044633	+	809	Protein_988	aminoglycoside nucleotidyltransferase ANT(9)	-
JZY07_RS05240	1044851..1045102	+	252	WP_002294510.1	hypothetical protein	-
JZY07_RS05245	1045153..1045611	-	459	WP_002325145.1	hypothetical protein	-
JZY07_RS05250	1045697..1046257	+	561	Protein_991	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	ant(6)-Ia / lsa(E) / lnu(B) / aph(3')-III / cat / erm(B)	-	1036462..1128323	91861

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 256 a.a.
• Molecular weight: 28985.80 Da
• Isoelectric Point: 5.1126

>T196161 WP_001235242.1 NZ_CP071305:1040987-1041754 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK

Nucleotide

• Length: 768 bp

>T196161 NZ_CP095022:701840-702241 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGGCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18266.77 Da
• Isoelectric Point: 4.6424

>AT196161 WP_000578719.1 NZ_CP071305:1040511-1040987 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT196161 NZ_CP095022:701598-701843 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Structures

Toxin

• AlphaFold DB: G7SEB4