Detailed information of TA system TA196092

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 924247..924472
• Replicon: chromosome
• Accession: NZ_CP071263
• Organism: Escherichia coli strain MEI003

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: J0G23_RS04835
• Protein ID: WP_000813255.1
• Coordinates: 924247..924402 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	924414..924472 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J0G23_RS04780	919748..919891	+	144	Protein_953	hypothetical protein	-
J0G23_RS04785	920086..920253	-	168	WP_000216649.1	DUF3927 family protein	-
J0G23_RS04790	920250..920678	-	429	Protein_955	tellurite resistance TerB family protein	-
J0G23_RS04810	921312..922001	-	690	WP_001064889.1	bacteriophage antitermination protein Q	-
J0G23_RS04815	921998..922357	-	360	WP_001217464.1	RusA family crossover junction endodeoxyribonuclease	-
J0G23_RS04820	922370..923419	-	1050	WP_001265301.1	DUF968 domain-containing protein	-
J0G23_RS04825	923421..923699	-	279	WP_032320649.1	hypothetical protein	-
J0G23_RS04830	923766..924029	-	264	WP_000975572.1	hypothetical protein	-
J0G23_RS04835	924247..924402	-	156	WP_000813255.1	type I toxin-antitoxin system toxin HokD	Toxin
-	924414..924472	+	59	-	-	Antitoxin
J0G23_RS04840	925145..925840	+	696	WP_000892866.1	hypothetical protein	-
J0G23_RS04845	925853..926506	+	654	WP_052907105.1	class I SAM-dependent methyltransferase	-
J0G23_RS04850	926821..927720	-	900	WP_000566848.1	SMEK domain-containing protein	-
J0G23_RS04855	927973..928395	-	423	WP_001151251.1	DUF977 family protein	-
J0G23_RS04860	928436..929401	-	966	WP_000054501.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleH2 / nleB2	889077..937586	48509

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5726.85 Da
• Isoelectric Point: 6.1531

>T196092 WP_000813255.1 NZ_CP071263:c924402-924247 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYESEE

Nucleotide

• Length: 156 bp

>T196092 NZ_CP095020:c3799347-3798955 [Mycobacterium tuberculosis]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT196092 NZ_CP071263:924414-924472 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Structures

Antitoxin