Detailed information of TA system TA195490

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3997981..3998497
• Replicon: chromosome
• Accession: NZ_CP071150
• Organism: Klebsiella pneumoniae strain IRQBAS102c

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JZ790_RS19595
• Protein ID: WP_117260273.1
• Coordinates: 3998213..3998497 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: JZ790_RS19590
• Protein ID: WP_002886901.1
• Coordinates: 3997981..3998223 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZ790_RS19575	3994009..3994749	+	741	WP_002886899.1	KDGP aldolase family protein	-
JZ790_RS19580	3994816..3995970	+	1155	WP_002886900.1	lactonase family protein	-
JZ790_RS19585	3995993..3997903	+	1911	WP_004152270.1	BglG family transcription antiterminator	-
JZ790_RS19590	3997981..3998223	+	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JZ790_RS19595	3998213..3998497	+	285	WP_117260273.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JZ790_RS19600	3998501..3998965	-	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
JZ790_RS19605	3999207..4001345	-	2139	WP_040164650.1	anaerobic ribonucleoside-triphosphate reductase	-
JZ790_RS19610	4001702..4002445	-	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
JZ790_RS19615	4002448..4002621	-	174	WP_032410138.1	hypothetical protein	-
JZ790_RS19620	4002706..4003014	+	309	WP_012737232.1	PTS sugar transporter subunit IIB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11127.96 Da
• Isoelectric Point: 10.3787

>T195490 WP_117260273.1 NZ_CP071150:3998213-3998497 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQVVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T195490 NZ_CP094743:348133-348384 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAGAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTGGTCTATAAATATGAGGAGGAACAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT195490 WP_002886901.1 NZ_CP071150:3997981-3998223 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT195490 NZ_CP094743:348374-348547 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCCGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AAGGGGACGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0