Detailed information of TA system TA195489

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3825148..3826829
• Replicon: chromosome
• Accession: NZ_CP071150
• Organism: Klebsiella pneumoniae strain IRQBAS102c

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: JZ790_RS18740
• Protein ID: WP_015959269.1
• Coordinates: 3825954..3826829 (+)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: JZ790_RS18735
• Protein ID: WP_130947194.1
• Coordinates: 3825148..3825906 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZ790_RS18720	3820998..3821684	-	687	WP_004151733.1	sel1 repeat family protein	-
JZ790_RS18725	3821914..3824061	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
JZ790_RS18730	3824334..3825062	+	729	WP_004177810.1	response regulator transcription factor	-
JZ790_RS18735	3825148..3825906	+	759	WP_130947194.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JZ790_RS18740	3825954..3826829	+	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JZ790_RS18745	3826954..3827961	-	1008	WP_015959270.1	carbohydrate kinase family protein	-
JZ790_RS18750	3828036..3828977	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
JZ790_RS18755	3829008..3830006	-	999	WP_002885172.1	ribose ABC transporter permease	-
JZ790_RS18760	3830003..3831523	-	1521	WP_049005954.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T195489 WP_015959269.1 NZ_CP071150:3825954-3826829 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

>T195489 NZ_CP094742:873648-873812 [Staphylococcus chromogenes]
ATGACAGAAGAAAAACATATCGAACATGAAAATGAAATGGTCGATGATTTTGATGATCTTGTCAGTTTAGGGAAAGAAAT
GGAACAAATTTCTGAAGCGAATGACGAAGAAAAAGTGAACCAAACACATGACGCATCTATTCGTTCAGATAAAACTGAAG
AATAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28532.93 Da
• Isoelectric Point: 10.0870

>AT195489 WP_130947194.1 NZ_CP071150:3825148-3825906 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQAVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT195489 NZ_CP094742:873031-873630 [Staphylococcus chromogenes]
ATGGCAATGAACTTTAAAGTTTTTAAAGATAAAGATACTGCAGCAATTTATGCAGCAGATATCATCAGAAAACAATTTAA
CAATAATCCTACGACAATTGCTGGATTTCATTTGAGTGGTGAAGAAGCACCAGTATTAGACTATTTAAAGCGCAATGTAG
ATGATCATGCCGTAGATTTTAGTCAAATTCATGTGCTAGATTATGACAAGCAAACATCATATTTTAAAGCGTTAGGTGTA
CCAGAAAAACAAATTCATGAAATTCCAGAAGATGACGATGTTGAAAAATTTATCGAACATAAAGCGAAAACAAAAGATAA
TAAAGGCAAATTGACACTACAAGTTGTTTCTATTAATCAGAATGGTGAATTCGGAGTACCAGTGAACAATGGTTTAAAAC
CTGCGCGTGAAATTTTTGTCATTGTGACAGGACATGATAAAGCTGATGTTATTAAAAAGTTATATGAAGATAATGGTAAT
ACAAGCTTTATTCCATCAAGCTTAAAAACGCACCGTATGGTGAATGTCATTTTAGACGAAGCTGCAGCCCAAGGTTTGCC
AGCTGATGTCAGAGAATATTTCACTTCTCTATATGCATAA

Structures

Toxin

• AlphaFold DB: A6TH06