Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2234302..2234888 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag JZL63_RS10375 Protein ID WP_003410010.1
Coordinates 2234302..2234646 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag JZL63_RS10380 Protein ID WP_003410014.1
Coordinates 2234640..2234888 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS10340 2230008..2230607 + 600 WP_206280157.1 L-lysine exporter -
JZL63_RS10345 2231023..2231451 + 429 WP_003409992.1 cellulose-binding protein -
JZL63_RS10350 2231677..2232216 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
JZL63_RS10355 2232736..2233296 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
JZL63_RS10360 2233293..2233634 - 342 WP_003410003.1 DUF2384 domain-containing protein -
JZL63_RS10365 2233720..2233977 + 258 WP_003410006.1 hypothetical protein -
JZL63_RS10370 2233878..2234213 - 336 WP_003410009.1 dehydrogenase -
JZL63_RS10375 2234302..2234646 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
JZL63_RS10380 2234640..2234888 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
JZL63_RS10385 2234988..2237303 - 2316 WP_206280158.1 cadmium-translocating P-type ATPase -
JZL63_RS10390 2237300..2237572 - 273 WP_206280159.1 DUF1490 family protein -
JZL63_RS10395 2237625..2237981 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
JZL63_RS10400 2238138..2238905 + 768 WP_206280160.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T195425 WP_003410010.1 NZ_CP071128:c2234646-2234302 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

>T195425 NZ_CP094718:c1662162-1661809 [Staphylococcus sp. IVB6240]
ATGAAGCGCGGGGATGTATACTTAGCTGATTTATCACCAGTACGGGGTTCTGAACAAGGGGGAGTGAGACCCGTCGTTAT
CATTCAAAATGATACTGGTAACAAATATAGTCCGACTGTTATCGTGGCAGCGATAACAGGTCGTATTAACAAAGCAAAGA
TTCCAACACATGTTGAAATTGAAAAAAAGAAGTATAAGCTCGACAAAGATTCAGTTATTTTATTAGAACAAATTCGAACA
GTAGATAAAAATCGTTTGAAAGAAAAGTTGACTTTTTTATCAGAAGAAAAGATGAAAGAAGTGAACAATGCTTTGGGGAT
TAGTCTTGGCTTACAAGTTGTTCAATCACGATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT195425 WP_003410014.1 NZ_CP071128:c2234888-2234640 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp

>AT195425 NZ_CP094718:c1662333-1662163 [Staphylococcus sp. IVB6240]
ATGTCAGTATTCAATCAAGTGAAGTTTAAAAATTTAGAGCAGTCATTAAAAGAAGGGTACGCCCAAATGGCTGACCTCAA
TCTCTCCCTAGCGACAGAAGCATATTCAGTAGAGTGTGAAGCATGCGATTGCAATGAGTCACACTTATTATCCAAGCATC
AGGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
PDB 7WJ0
PDB 7WNR
AlphaFold DB A0A7U4FAW9

References