Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2203678..2204222 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag JZL63_RS10190 Protein ID WP_003409896.1
Coordinates 2203678..2203974 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag JZL63_RS10195 Protein ID WP_003409899.1
Coordinates 2203971..2204222 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS10135 2198711..2199061 - 351 WP_206281223.1 hypothetical protein -
JZL63_RS10140 2199072..2199974 - 903 WP_003899097.1 hypothetical protein -
JZL63_RS10145 2199995..2200186 - 192 WP_003409876.1 hypothetical protein -
JZL63_RS10150 2200187..2200483 - 297 WP_003409877.1 hypothetical protein -
JZL63_RS10155 2200723..2200938 + 216 WP_003409878.1 antitoxin -
JZL63_RS10160 2200935..2201246 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
JZL63_RS10165 2201220..2201741 - 522 WP_003904745.1 hypothetical protein -
JZL63_RS10170 2201716..2202093 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
JZL63_RS10175 2202135..2202584 + 450 WP_206281224.1 helix-turn-helix domain-containing protein -
JZL63_RS10180 2202581..2203126 + 546 WP_003409891.1 SecB-like chaperone -
JZL63_RS10185 2203015..2203629 - 615 WP_003901296.1 hypothetical protein -
JZL63_RS10190 2203678..2203974 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JZL63_RS10195 2203971..2204222 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JZL63_RS10200 2204209..2204703 + 495 WP_003899099.1 hypothetical protein -
JZL63_RS10205 2204863..2205270 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
JZL63_RS10210 2205274..2205546 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JZL63_RS10215 2205579..2206799 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
JZL63_RS10220 2207697..2208494 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T195422 WP_003409896.1 NZ_CP071128:c2203974-2203678 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T195422 NZ_CP094717:c1654114-1653893 [Staphylococcus sp. IVB6246]
GTGCACAGCAAAGTATGGTTATCAGGTCTCTCGAGTGAGGAGCAAAAGCAACAGCTTGAATCGCGCCTGAGAGATATGAT
TGGTGTTGAAACGGCAGAGGTCGACATCGACAAGCAAATTGTGATTTTGACGTATGAAACCCCAGCCAATCTAAACACAT
TAGAAAAAGAAATTTATGATGCAGGTTACCCTGTTATTAATTCATATAAAGGAGAAGATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT195422 WP_003409899.1 NZ_CP071128:c2204222-2203971 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT195422 NZ_CP094717:c1654415-1654128 [Staphylococcus sp. IVB6246]
ATGATAGAACATGCGAATCATTCTGAAGTGACAAAACGCAATTTGCAATCCCGTTTAAATCGCATTGAAGGTCAAGTGCG
TGCAATTAATCGTATGATTGAAGAAGATGTTTATTGTGATGATGTCTTAACACAAATTCGTGCTACGAGATCGGCTTTAA
ATAGTGTAGCTTCGAAATTGTTAGAACATCATATGAAAGGGTGTATTTTGCATAAAGTTGAAGGTGGGAATGAGCAAGAA
GCAATGGATGAATTGCTTGTGACATTCCAAAAGTTGATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References