Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1686268..1686884 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag JZL63_RS07820 Protein ID WP_003407593.1
Coordinates 1686567..1686884 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag JZL63_RS07815 Protein ID WP_003900349.1
Coordinates 1686268..1686570 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS07805 1682154..1684001 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
JZL63_RS07810 1684002..1686254 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
JZL63_RS07815 1686268..1686570 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
JZL63_RS07820 1686567..1686884 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
JZL63_RS07825 1686881..1687885 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
JZL63_RS07830 1687938..1689227 + 1290 WP_206281117.1 serine hydrolase -
JZL63_RS07835 1689300..1690073 - 774 WP_206281254.1 methyltransferase domain-containing protein -
JZL63_RS07840 1690131..1690343 - 213 WP_003898900.1 dodecin family protein -
JZL63_RS07845 1690353..1690577 - 225 WP_160522526.1 NUDIX domain-containing protein -
JZL63_RS07850 1690847..1691875 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T195416 WP_003407593.1 NZ_CP071128:1686567-1686884 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T195416 NZ_CP094715:820324-820686 [Staphylococcus pasteuri]
ATGATTAGAAGAGGAGATGTTTATCTAGCAGATTTATCACCTGTTCAAGGGTCCGAACAAGGGGGAGTAAGACCCGTCGT
TATTATTCAAAATGACACAGGTAATAAATATAGTCCAACAGTAATTGTTGCAGCAATTACTGGAAGGATTAACAAAGCTA
AGATACCCACACATGTAGAAATAGAAAAGAAGAAGTATAAACTTGATAAAGATTCTGTAATCTTACTTGAACAAATTCGA
ACGTTAGATAAAAATCGTTTGAAAGAAAAGCTCACATATTTGTCAGAAAACAAAATGAAAGAAGTAGATTACGCCCTAGA
CATCAGTCTAGGTTTACATAATTTTAATCATCCAAAGACTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT195416 WP_003900349.1 NZ_CP071128:1686268-1686570 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT195416 NZ_CP094715:820157-820327 [Staphylococcus pasteuri]
ATGTTATCTTTTAATCAAAATAGAAGTTACAGTTTAGAGCAATCTTTAAAAGAAGGTTATGCACAAATGGCTGATTTAAA
TCTCTCCCTAGCAACCGAAGCTTTTCCAATTGAATGTGAAGCGTGCGATTGCAATGAAACATATTTAACTTCTAACGCTA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References