Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 710781..711406 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag JZL63_RS03220 Protein ID WP_003403218.1
Coordinates 711005..711406 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag JZL63_RS03215 Protein ID WP_003403213.1
Coordinates 710781..711008 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS03190 705960..706181 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JZL63_RS03195 706323..706928 + 606 WP_003898526.1 hypothetical protein -
JZL63_RS03200 706947..709514 - 2568 WP_206280898.1 SEC-C domain-containing protein -
JZL63_RS03205 709598..710347 + 750 WP_003898528.1 hypothetical protein -
JZL63_RS03210 710344..710586 + 243 WP_003403210.1 hypothetical protein -
JZL63_RS03215 710781..711008 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
JZL63_RS03220 711005..711406 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
JZL63_RS03225 711535..712230 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
JZL63_RS03230 712227..712718 + 492 WP_096871919.1 galactose-1-phosphate uridylyltransferase -
JZL63_RS03235 712715..713806 + 1092 WP_206280899.1 galactokinase -
JZL63_RS03240 714201..715265 + 1065 WP_003898532.1 hypothetical protein -
JZL63_RS03245 715369..716316 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T195399 WP_003403218.1 NZ_CP071128:711005-711406 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T195399 NZ_CP094707:982934-983284 [Staphylococcus simulans]
ATGATGAGGAGAGGCGATGTTTATTTAGCTGATTTATCACCAGTGCAAGGTTCTGAACAAGGGGGAGTTAGACCTGTTGT
AATTATACAAAATGACACTGGCAATAAGTACAGTCCGACGGTAATTGTAGCCGCGATTACTGGGCGTATTAATAAGGCGA
AAATTCCAACGCATGTTGAAATTGAAAAGAGTAAATACAAATTAGACAAAGATTCTGTTATATTACTTGAACAGATTAGA
ACAGTTGATAAAAAACGTTTGAAAGAGAAATTGACTTATCTTTCAGATGAGAAGATGAAAGAAATTGATAACGCGATTGG
AATTAGTTTAGGCTTGACACATAAAAATTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT195399 WP_003403213.1 NZ_CP071128:710781-711008 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT195399 NZ_CP094707:982770-982937 [Staphylococcus simulans]
ATGTCAACTTTTAATCAGAATAGAAGCTATAGTTTGGAACAGTCATTAAAAGAAGGCTATTCACAAATGGCTGATTTGAA
TCTCTCCCTAGCAACGGAGGCATTTTCAGTGGAATGTGAAGCCTGTGATTGCAATGAATCTTATCTTACATTTGATAAGG
ATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References