Detailed information of TA system TA195282

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 11376..11867
• Replicon: chromosome
• Accession: NZ_CP071096
• Organism: Fusobacterium polymorphum strain THCT7E2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JY402_RS12175
• Protein ID: WP_258876714.1
• Coordinates: 11736..11867 (+)
• Length: 44 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0S1YWU3
• Locus tag: JY402_RS00055
• Protein ID: WP_060496615.1
• Coordinates: 11376..11600 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JY402_RS00035 (JY402_00035)	6407..7882	+	1476	WP_220283121.1	cobyric acid synthase	-
JY402_RS00040 (JY402_00040)	8008..8643	+	636	Protein_7	alanine:cation symporter family protein	-
JY402_RS00045 (JY402_00045)	9217..10464	+	1248	WP_220283122.1	RNA-guided endonuclease TnpB family protein	-
JY402_RS00050 (JY402_00050)	10545..11306	+	762	Protein_9	alanine:cation symporter family protein	-
JY402_RS00055 (JY402_00055)	11376..11600	+	225	WP_060496615.1	DUF6290 family protein	Antitoxin
JY402_RS12175	11736..11867	+	132	WP_258876714.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JY402_RS00065 (JY402_00065)	12065..12466	+	402	WP_005898370.1	IS200/IS605 family transposase	-
JY402_RS00070 (JY402_00070)	12479..13906	+	1428	WP_220283123.1	transposase	-
JY402_RS00075 (JY402_00075)	14110..15042	+	933	Protein_14	dGTP triphosphohydrolase	-
JY402_RS00080 (JY402_00080)	15064..15603	+	540	WP_032835187.1	TlpA disulfide reductase family protein	-
JY402_RS00085 (JY402_00085)	15636..16061	-	426	WP_032890325.1	ImmA/IrrE family metallo-endopeptidase	-
JY402_RS00090 (JY402_00090)	16012..16479	-	468	WP_005901035.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	12095..12466	371

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-41)

Antitoxin

• Protein of unknown function DUF6290 (1-72)

Sequences

Toxin

Protein

• Length: 44 a.a.
• Molecular weight: 5287.26 Da
• Isoelectric Point: 9.9903

>T195282 WP_258876714.1 NZ_CP071096:11736-11867 [Fusobacterium polymorphum]
MLGNLKDYWRYRIGDYRLITKIDDGKLLIIALELKHRKEAYKY

Nucleotide

• Length: 132 bp

>T195282 NZ_CP094479:c2638434-2637112 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCACTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCCGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACACCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGTTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8727.07 Da
• Isoelectric Point: 5.8834

>AT195282 WP_060496615.1 NZ_CP071096:11376-11600 [Fusobacterium polymorphum]
MSNITLRLTDEEREILNNVAHLYADKLSTAIKTILFEKIEEDYNLKIVKDFEKREKENKVELVSLSDFRKKLGV

Nucleotide

• Length: 225 bp

>AT195282 NZ_CP094479:c2638700-2638434 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0S1YWU3