Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4016431..4017050 Replicon chromosome
Accession NZ_CP071080
Organism Klebsiella pneumoniae strain 3347684I

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JY393_RS19385 Protein ID WP_002892050.1
Coordinates 4016832..4017050 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JY393_RS19380 Protein ID WP_002892066.1
Coordinates 4016431..4016805 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY393_RS19370 (4011583) 4011583..4012776 + 1194 WP_211652293.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JY393_RS19375 (4012799) 4012799..4015945 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JY393_RS19380 (4016431) 4016431..4016805 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JY393_RS19385 (4016832) 4016832..4017050 + 219 WP_002892050.1 HHA domain-containing protein Toxin
JY393_RS19390 (4017209) 4017209..4017775 + 567 WP_002892030.1 maltose O-acetyltransferase -
JY393_RS19395 (4017747) 4017747..4017887 - 141 WP_004147370.1 hypothetical protein -
JY393_RS19400 (4017908) 4017908..4018378 + 471 WP_002892026.1 YlaC family protein -
JY393_RS19405 (4018353) 4018353..4019804 - 1452 WP_004177237.1 PLP-dependent aminotransferase family protein -
JY393_RS19410 (4019905) 4019905..4020603 + 699 WP_004177238.1 GNAT family protein -
JY393_RS19415 (4020600) 4020600..4020740 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JY393_RS19420 (4020740) 4020740..4021003 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T195250 WP_002892050.1 NZ_CP071080:4016832-4017050 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T195250 NZ_CP094454:8225-8641 [Klebsiella pneumoniae subsp. rhinoscleromatis]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT195250 WP_002892066.1 NZ_CP071080:4016431-4016805 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT195250 NZ_CP094454:7998-8228 [Klebsiella pneumoniae subsp. rhinoscleromatis]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References